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    Cplane1 ciliogenesis and planar polarity effector complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cplane1provided by RGD
    Official Full Name
    ciliogenesis and planar polarity effector complex subunit 1provided by RGD
    Primary source
    RGD:1310081
    See related
    EnsemblRapid:ENSRNOG00000042118 AllianceGenome:RGD:1310081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310081
    Summary
    Predicted to be involved in cilium assembly. Predicted to act upstream of or within several processes, including embryonic digit morphogenesis; heart development; and protein localization to ciliary transition zone. Predicted to be active in ciliary transition zone. Human ortholog(s) of this gene implicated in Joubert syndrome 17 and Joubert syndrome with orofaciodigital defect. Orthologous to human CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 97.6), Testes (RPKM 45.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cplane1 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (58996119..59096817)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (57269195..57369580)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (57274175..57350003) , (57444373..57472465)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 70 Neighboring gene phospholipase D family, member 6, pseudogene 1 Neighboring gene uncharacterized LOC120100734 Neighboring gene nucleoporin 155 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 29 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 8 Neighboring gene ribosomal protein L9, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of planar polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ciliogenesis and planar polarity effector 1
    Names
    uncharacterized protein C5orf42 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427186.1 → NP_001414115.1  ciliogenesis and planar polarity effector 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Related
      ENSRNOP00000110500.1, ENSRNOT00000159645.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      58996119..59096817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281736.1 → XP_063137806.1  ciliogenesis and planar polarity effector 1 isoform X1

    2. XM_063281741.1 → XP_063137811.1  ciliogenesis and planar polarity effector 1 isoform X7

    3. XM_063281738.1 → XP_063137808.1  ciliogenesis and planar polarity effector 1 isoform X3

    4. XM_063281737.1 → XP_063137807.1  ciliogenesis and planar polarity effector 1 isoform X2

    5. XM_063281739.1 → XP_063137809.1  ciliogenesis and planar polarity effector 1 isoform X4

    6. XM_063281740.1 → XP_063137810.1  ciliogenesis and planar polarity effector 1 isoform X5

    7. XM_039103529.2 → XP_038959457.1  ciliogenesis and planar polarity effector 1 isoform X6

      Related
      ENSRNOP00000099282.1, ENSRNOT00000161521.1
      Conserved Domains (1) summary
      pfam15392
      Location:2972 → 3263
      Joubert; Joubert syndrome-associated

    8. XM_039103531.2 → XP_038959459.1  ciliogenesis and planar polarity effector 1 isoform X11

      UniProtKB/TrEMBL
      D3ZK35
      Related
      ENSRNOP00000060886.4, ENSRNOT00000063899.5
      Conserved Domains (1) summary
      pfam15392
      Location:2949 → 3240
      Joubert; Joubert syndrome-associated

    9. XM_063281742.1 → XP_063137812.1  ciliogenesis and planar polarity effector 1 isoform X8

    10. XM_063281743.1 → XP_063137813.1  ciliogenesis and planar polarity effector 1 isoform X9

    11. XM_039103535.2 → XP_038959463.1  ciliogenesis and planar polarity effector 1 isoform X10

      Conserved Domains (1) summary
      pfam15392
      Location:1700 → 1991
      Joubert; Joubert syndrome-associated
    Nucleotide Protein Strain
    Heading Accession and Version

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