U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Tbc1d32 TBC1 domain family, member 32 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100359595, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tbc1d32provided by RGD
    Official Full Name
    TBC1 domain family, member 32provided by RGD
    Primary source
    RGD:2323599
    See related
    EnsemblRapid:ENSRNOG00000000802 AllianceGenome:RGD:2323599
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in non-motile cilium assembly. Predicted to act upstream of or within several processes, including camera-type eye development; embryonic digit morphogenesis; and regionalization. Orthologous to human TBC1D32 (TBC1 domain family member 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 42.5), Brain (RPKM 40.2) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tbc1d32 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (35902281..36133161, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (35359865..35590992, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (37463879..37701268, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RAB1A, member RAS oncogene family, pseudogene 5 Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 7 Neighboring gene male-specific lethal 3-like 2 Neighboring gene inactive serine/threonine-protein kinase VRK3 pseudogene Neighboring gene gap junction protein, alpha 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Ko HW, et al. Dev Cell, 2010 Feb 16. PMID 20159594, Free PMC Article
    2. Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. Wang C, et al. Development, 2018 Mar 15. PMID 29487109, Free PMC Article
    3. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube patterning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retinal pigment epithelium development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway involved in dorsal/ventral neural tube patterning ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein broad-minded

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      35902281..36133161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099304.2 → XP_038955232.1  protein broad-minded isoform X1

      UniProtKB/TrEMBL
      D4A050
      Related
      ENSRNOP00000001051.8, ENSRNOT00000001051.9
      Conserved Domains (1) summary
      pfam14961
      Location:12 → 1297
      BROMI; Broad-minded protein

    2. XM_039099306.2 → XP_038955234.1  protein broad-minded isoform X2

      UniProtKB/TrEMBL
      D4A050
      Conserved Domains (1) summary
      pfam14961
      Location:2 → 1070
      BROMI; Broad-minded protein

    3. XM_063279629.1 → XP_063135699.1  protein broad-minded isoform X6

    4. XM_039099307.2 → XP_038955235.1  protein broad-minded isoform X3

      Conserved Domains (1) summary
      pfam14961
      Location:12 → 1047
      BROMI; Broad-minded protein

    5. XM_063279628.1 → XP_063135698.1  protein broad-minded isoform X4

    6. XM_039099308.2 → XP_038955236.1  protein broad-minded isoform X5

      Conserved Domains (1) summary
      pfam14961
      Location:12 → 1044
      BROMI; Broad-minded protein

    7. XM_039099310.2 → XP_038955238.1  protein broad-minded isoform X8

      Conserved Domains (1) summary
      pfam14961
      Location:12 → 830
      BROMI; Broad-minded protein

    8. XM_039099309.2 → XP_038955237.1  protein broad-minded isoform X7

      Conserved Domains (1) summary
      pfam14961
      Location:12 → 830
      BROMI; Broad-minded protein

    9. XM_039099311.2 → XP_038955239.1  protein broad-minded isoform X9

      Conserved Domains (1) summary
      pfam14961
      Location:12 → 724
      BROMI; Broad-minded protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.