Kcnq2 potassium voltage-gated channel subfamily Q member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnq2provided by RGD
Official Full Name: potassium voltage-gated channel subfamily Q member 2provided by RGD
Primary source: RGD:621504
See related: EnsemblRapid:ENSRNOG00000011624 AllianceGenome:RGD:621504
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport. Located in axon initial segment and plasma membrane. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in benign neonatal seizures and developmental and epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 159.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (188572345..188631391, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (168194776..168253831, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (176585897..176645029, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain.
Title: Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain.
Persistent Kv7.2/7.3 downregulation in the rat pilocarpine model of mesial temporal lobe epilepsy.
Title: Persistent Kv7.2/7.3 downregulation in the rat pilocarpine model of mesial temporal lobe epilepsy.
Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats.
Title: Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats.
Posttranscriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family.
Title: Posttranscriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family.
The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels.
Title: The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels.
Kv7.2 subunit-containing M-type potassium channels in the lateral habenula are involved in the regulation of working memory in parkinsonian rats.
Title: Kv7.2 subunit-containing M-type potassium channels in the lateral habenula are involved in the regulation of working memory in parkinsonian rats.
Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy.
Title: Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy.
the M channel is not expressed in rat adrenal medulla cells and this absence of expression may be ascribed to the suppression by glucocorticoid activity.
Title: Expression and regulation of M-type K(+) channel in PC12 cells and rat adrenal medullary cells.
Our results suggest that KCNQ2 channels are involved in regulating orofacial cold sensitivity
Title: Role of KCNQ2 channels in orofacial cold sensitivity: KCNQ2 upregulation in trigeminal ganglion neurons after infraorbital nerve chronic constrictive injury.
RNA interference-mediated silencing of KCNQ2 is a suitable approach to create an ex vivo model for testing the specificity of novel Kv7.2/Kv7.3 agonists.
Title: RNA interference-based functional knockdown of the voltage-gated potassium channel Kv7.2 in dorsal root ganglion neurons after in vitro and in vivo gene transfer by adeno-associated virus vectors.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:495992 (e-PCR)
- UniSTS:495992

Kcnq2 (e-PCR), detects polymorphism
- UniSTS:495992

Kcnq2 (e-PCR), detects polymorphism
- UniSTS:259498

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ankyrin binding	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within action potential initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dentate gyrus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within excitatory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exploration behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within grooming behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hippocampal pyramidal neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inhibitory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motor behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nerve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within psychomotor behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of action potential firing threshold	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to auditory stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to temperature stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within social behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substantia propria of cornea development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in node of Ranvier	ISO Inferred from Sequence Orthology more info
located_in node of Ranvier	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily KQT member 2

Names: KQT-like 2; potassium channel subunit alpha KvLQT2; potassium channel, voltage-gated KQT-like subfamily Q, member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; voltage-gated potassium channel subunit Kv7.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133322.2 → NP_579856.2 potassium voltage-gated channel subfamily KQT member 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

O88943

UniProtKB/TrEMBL

A6KM54, F1M6X3

Related

ENSRNOP00000040830.4, ENSRNOT00000049961.6

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:448 → 634

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:748 → 848

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:649 → 736

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

188572345..188631391 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104178.2 → XP_038960106.1 potassium voltage-gated channel subfamily KQT member 2 isoform X2

UniProtKB/TrEMBL

A0A8I6AIP3

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:466 → 718

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:832 → 932

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:733 → 820

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017591445.3 → XP_017446934.1 potassium voltage-gated channel subfamily KQT member 2 isoform X15

UniProtKB/Swiss-Prot

O88943
XM_039104185.2 → XP_038960113.1 potassium voltage-gated channel subfamily KQT member 2 isoform X9

UniProtKB/Swiss-Prot

O88943

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:426 → 679

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:793 → 893

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:694 → 781

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_039104182.2 → XP_038960110.1 potassium voltage-gated channel subfamily KQT member 2 isoform X5

UniProtKB/Swiss-Prot

O88943

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:438 → 691

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:805 → 905

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:706 → 793

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_039104180.2 → XP_038960108.1 potassium voltage-gated channel subfamily KQT member 2 isoform X3

UniProtKB/TrEMBL

A0A8I6AIP3

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:456 → 709

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:823 → 923

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:724 → 811

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_039104183.2 → XP_038960111.1 potassium voltage-gated channel subfamily KQT member 2 isoform X6

UniProtKB/Swiss-Prot

O88943

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:436 → 689

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:803 → 903

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:704 → 791

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_039104181.2 → XP_038960109.1 potassium voltage-gated channel subfamily KQT member 2 isoform X4

UniProtKB/Swiss-Prot

O88943

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:448 → 701

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:815 → 915

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:716 → 803

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_039104184.2 → XP_038960112.1 potassium voltage-gated channel subfamily KQT member 2 isoform X8

UniProtKB/TrEMBL

A0A8I6AIP3

Related

ENSRNOP00000083195.2, ENSRNOT00000102525.2

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:466 → 683

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:797 → 897

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:698 → 785

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_039104177.2 → XP_038960105.1 potassium voltage-gated channel subfamily KQT member 2 isoform X1

UniProtKB/TrEMBL

A0A8I6AIP3

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:466 → 719

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:833 → 933

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:734 → 821

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_006235725.5 → XP_006235787.1 potassium voltage-gated channel subfamily KQT member 2 isoform X11

UniProtKB/Swiss-Prot

O88943

Related

ENSRNOP00000094215.1, ENSRNOT00000094525.2

Conserved Domains (5) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:444 → 666

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel

pfam11956
Location:784 → 874

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:675 → 762

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_039104186.2 → XP_038960114.1 potassium voltage-gated channel subfamily KQT member 2 isoform X12

UniProtKB/Swiss-Prot

O88943

Conserved Domains (4) summary

pfam00520
Location:92 → 324

Ion_trans; Ion transport protein

pfam03520
Location:438 → 655

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam11956
Location:769 → 869

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:670 → 757

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017591447.3 → XP_017446936.1 potassium voltage-gated channel subfamily KQT member 2 isoform X18

UniProtKB/Swiss-Prot

O88943
XM_017591443.3 → XP_017446932.1 potassium voltage-gated channel subfamily KQT member 2 isoform X10

UniProtKB/Swiss-Prot

O88943
XM_063283035.1 → XP_063139105.1 potassium voltage-gated channel subfamily KQT member 2 isoform X14

UniProtKB/TrEMBL

A0A8I6AIP3
XM_006235721.5 → XP_006235783.1 potassium voltage-gated channel subfamily KQT member 2 isoform X7

UniProtKB/TrEMBL

A0A8I6AIP3

Conserved Domains (5) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:472 → 694

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel

pfam11956
Location:812 → 902

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:703 → 790

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_008762462.4 → XP_008760684.1 potassium voltage-gated channel subfamily KQT member 2 isoform X19

UniProtKB/TrEMBL

A0A8I6B1F5, A6KM53

Conserved Domains (3) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:472 → 618

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel
XM_006235729.5 → XP_006235791.1 potassium voltage-gated channel subfamily KQT member 2 isoform X17

UniProtKB/Swiss-Prot

O88943

Conserved Domains (5) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:444 → 630

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel

pfam11956
Location:748 → 838

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:639 → 726

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_017591446.3 → XP_017446935.1 potassium voltage-gated channel subfamily KQT member 2 isoform X16

UniProtKB/Swiss-Prot

O88943
XM_006235727.5 → XP_006235789.1 potassium voltage-gated channel subfamily KQT member 2 isoform X13

UniProtKB/TrEMBL

A0A8I5ZWG8, A0A8I6AIP3

Conserved Domains (5) summary

pfam00520
Location:119 → 324

Ion_trans; Ion transport protein

pfam03520
Location:472 → 658

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:240 → 314

Ion_trans_2; Ion channel

pfam11956
Location:776 → 866

KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

pfam16642
Location:667 → 754

KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2
XM_063283036.1 → XP_063139106.1 potassium voltage-gated channel subfamily KQT member 2 isoform X20

UniProtKB/TrEMBL

A6KM55

Related

ENSRNOP00000094730.1, ENSRNOT00000109229.2