Rnf114 ring finger protein 114 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf114provided by RGD
Official Full Name: ring finger protein 114provided by RGD
Primary source: RGD:1303139
See related: EnsemblRapid:ENSRNOG00000060821 AllianceGenome:RGD:1303139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zfp313; Znf313
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and plasma membrane. Orthologous to human RNF114 (ring finger protein 114). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 210.5), Adrenal (RPKM 183.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (176641456..176653262)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (156222487..156234263)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (164248736..164260499)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF114

Names: RING-type E3 ubiquitin transferase RNF114; zinc finger protein 313

NP_001001517.1

EC 2.3.2.27

XP_008760737.1

EC 2.3.2.27

XP_063140300.1

EC 2.3.2.27

XP_063140301.1

EC 2.3.2.27

XP_063140302.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001517.2 → NP_001001517.1 E3 ubiquitin-protein ligase RNF114

See identical proteins and their annotated locations for NP_001001517.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q4G096, Q6J2U6

UniProtKB/TrEMBL

A6JXK5

Conserved Domains (3) summary

cd16540
Location:28 → 69

RING-HC_RNF114; RING finger, HC subclass, found in RING finger protein 114 (RNF114) and similar proteins

pfam05605
Location:141 → 201

zf-Di19; Drought induced 19 protein (Di19), zinc-binding

pfam18574
Location:86 → 118

zf_C2HC_14; C2HC Zing finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

176641456..176653262

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284231.1 → XP_063140301.1 E3 ubiquitin-protein ligase RNF114 isoform X2
XM_063284232.1 → XP_063140302.1 E3 ubiquitin-protein ligase RNF114 isoform X4
XM_063284230.1 → XP_063140300.1 E3 ubiquitin-protein ligase RNF114 isoform X1
XM_008762515.4 → XP_008760737.1 E3 ubiquitin-protein ligase RNF114 isoform X3

UniProtKB/TrEMBL

A0A8I5YBW4

Related

ENSRNOP00000068785.3, ENSRNOT00000086459.3

Conserved Domains (1) summary

pfam05605
Location:162 → 222

zf-Di19; Drought induced 19 protein (Di19), zinc-binding