Ghrhr growth hormone releasing hormone receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ghrhrprovided by RGD
Official Full Name: growth hormone releasing hormone receptorprovided by RGD
Primary source: RGD:2688
See related: EnsemblRapid:ENSRNOG00000011808 AllianceGenome:RGD:2688
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GHRHREC
Summary: Enables growth hormone-releasing hormone receptor activity. Involved in several processes, including activation of adenylate cyclase activity; cAMP/PKA signal transduction; and positive regulation of circadian sleep/wake cycle, non-REM sleep. Located in cell surface and sarcolemma. Used to study isolated growth hormone deficiency. Biomarker of sleep disorder. Human ortholog(s) of this gene implicated in isolated growth hormone deficiency and isolated growth hormone deficiency type IB. Orthologous to human GHRHR (growth hormone releasing hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 6.3), Spleen (RPKM 3.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (85830345..85863127)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (84498159..84532851)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (85587321..85602389)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that cardiac stem cells (CSCs) isolated from mouse, rat and pig myocardium express growth hormone-releasing hormone receptor (GHRH-R) and agonists of GHRH-R stimulate their proliferation and survival.
Title: Agonists of growth hormone-releasing hormone stimulate self-renewal of cardiac stem cells and promote their survival.
Data show alterations in growth hormone (GH) synthesis and expression of GH-releasing hormone receptor (GHRH receptor) on cells of the immune system that may play a role in the immune response in aging.
Title: Expression of lymphocyte-derived growth hormone (GH) and GH-releasing hormone receptors in aging rats.
GHRH protects the heart from I/R injury through GHRHR-mediated mechanisms, leading to activation of RISK and SAFE pathways, which converge on mitochondria and possibly on AMP-activated protein kinase.
Title: GH-releasing hormone induces cardioprotection in isolated male rat heart via activation of RISK and SAFE pathways.
Activation of growth hormone releasing hormone receptor stimulates cardiac reverse remodeling after myocardial infarction.
Title: Activation of growth hormone releasing hormone (GHRH) receptor stimulates cardiac reverse remodeling after myocardial infarction (MI).
Genetic silencing of growth hormone-releasing hormone receptor (GHRHR) reduces cortical expression of GHRHR and suppresses non-rapid eye movement sleep electroencephalographic (EEG) delta wave power.
Title: Localized suppression of cortical growth hormone-releasing hormone receptors state-specifically attenuates electroencephalographic delta waves.
the effect of glucotoxicity would be related to a decrease of functional GHRH-R protein, as observed in rats 60 days post-streptozoticin and in cultured pituitary cells from healthy rats exposed to a high-glucose environment
Title: Effects of a high-glucose environment on the pituitary growth hormone-releasing hormone receptor: type 1 diabetes compared with in vitro glucotoxicity.
cortical GHRH and GHRHR have a role in the regulation of localized EEG delta power that is state dependent
Title: Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression.
Promoter is sufficient to direct tissue- and cell-specific expression in vivo and is regulated by Pit-1.
Title: Pituitary-specific expression and Pit-1 regulation of the rat growth hormone-releasing hormone receptor gene.
In the intrauterine growth restricted rat at one year of age, levels of pituitary GH, GH-R and GHRH-R relative gene expression were increased.
Title: Pituitary mRNA expression of the growth hormone axis in the 1-year-old intrauterine growth restricted rat.
Sleep loss alters hypothalamic growth hormone-releasing hormone receptors in rats
Title: Sleep loss alters hypothalamic growth hormone-releasing hormone receptors in rats.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables growth hormone-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone-releasing hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth hormone-releasing hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables growth hormone-releasing hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenohypophysis development	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in determination of adult lifespan	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in growth hormone secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in hormone metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hormone metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of growth hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of growth	TAS Traceable Author Statement more info	PubMed
involved_in regulation of insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of intracellular steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
involved_in somatotropin secreting cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatotropin secreting cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: growth hormone-releasing hormone receptor

Names: GHRH receptor; GRF receptor; GRFR; Growth hormone - releasing receptor; growth hormone-releasing factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398554.1 → NP_001385483.1 growth hormone-releasing hormone receptor isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A1B0HAQ2, A6K0Y0

Related

ENSRNOP00000092627.1, ENSRNOT00000112212.2

Conserved Domains (3) summary

pfam02793
Location:2 → 60

HRM; Hormone receptor domain

cd14964
Location:76 → 101

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:74 → 341

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001398565.1 → NP_001385494.1 growth hormone-releasing hormone receptor isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6K0X9, Q9WU99

Related

ENSRNOP00000071248.2, ENSRNOT00000084855.3

Conserved Domains (3) summary

pfam02793
Location:54 → 112

HRM; Hormone receptor domain

cd14964
Location:128 → 153

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:126 → 393

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_012850.3 → NP_036982.1 growth hormone-releasing hormone receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_036982.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6K0Y0

Related

ENSRNOP00000043884.3, ENSRNOT00000044578.4

Conserved Domains (2) summary

pfam00002
Location:126 → 372

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:54 → 112

HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

85830345..85863127

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285596.1 → XP_063141666.1 growth hormone-releasing hormone receptor isoform X3
XM_063285595.1 → XP_063141665.1 growth hormone-releasing hormone receptor isoform X2
XM_063285594.1 → XP_063141664.1 growth hormone-releasing hormone receptor isoform X2
XM_063285593.1 → XP_063141663.1 growth hormone-releasing hormone receptor isoform X2
XM_063285597.1 → XP_063141667.1 growth hormone-releasing hormone receptor isoform X3
XM_063285598.1 → XP_063141668.1 growth hormone-releasing hormone receptor isoform X3
XM_063285592.1 → XP_063141662.1 growth hormone-releasing hormone receptor isoform X1