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    Nrf1 nuclear respiratory factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrf1provided by RGD
    Official Full Name
    nuclear respiratory factor 1provided by RGD
    Primary source
    RGD:1304603
    See related
    EnsemblRapid:ENSRNOG00000008752 AllianceGenome:RGD:1304603
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nfe2l1_retired
    Summary
    This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Confusion has occurred in bibliographic databases for genes in the "nuclear respiratory factor" and "nuclear factor (erythroid-derived 2)-like" families due to a shared symbol or alias of Nrf1. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Thymus (RPKM 147.5), Spleen (RPKM 95.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrf1 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59632366..59738166)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (58664932..58772328)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57335732..57445317)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small lysine-rich protein 1 Neighboring gene uncharacterized LOC120102484 Neighboring gene microRNA 182 Neighboring gene microRNA 96

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effects of nuclear respiratory factor‑1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells. Niu N, et al. Mol Med Rep, 2019 Mar. PMID 30628711, Free PMC Article
    2. Changes in mitochondrial DNA deletion, content, and biogenesis in folate-deficient tissues of young rats depend on mitochondrial folate and oxidative DNA injuries. Chou YF, et al. J Nutr, 2007 Sep. PMID 17709439
    3. Activity-dependent transcriptional regulation of nuclear respiratory factor-1 in cultured rat visual cortical neurons. Yang SJ, et al. Neuroscience, 2006 Sep 1. PMID 16753268
    4. Nrf1 is time-dependently expressed and distributed in the distinct cell types after trauma to skeletal muscles in rats. Zhang ST, et al. Histol Histopathol, 2013 Jun. PMID 23359427
    5. Stimulation of mitochondrial biogenesis and autophagy by lipopolysaccharide in the neonatal rat cardiomyocyte protects against programmed cell death. Hickson-Bick DL, et al. J Mol Cell Cardiol, 2008 Feb. PMID 18062988

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effect of 12-wk Training in Ovariectomised Rats on PGC-1alpha, NRF-1 and Energy Substrates.
      Title: Effect of 12-wk Training in Ovariectomised Rats on PGC-1α, NRF-1 and Energy Substrates.
    2. Effects of NRF-1 and PGC-1alpha cooperation on HIF-1alpha and rat cardiomyocyte apoptosis under hypoxia.
      Title: Effects of NRF-1 and PGC-1α cooperation on HIF-1α and rat cardiomyocyte apoptosis under hypoxia.
    3. Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.
      Title: Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.
    4. Testosterone attenuates pulmonary epithelial inflammation in male rats of COPD model through preventing NRF1-derived NF-kappaB signaling.
      Title: Testosterone attenuates pulmonary epithelial inflammation in male rats of COPD model through preventing NRF1-derived NF-κB signaling.
    5. Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.
      Title: Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.
    6. NRF1-enhanced miR-4458 alleviates cardiac hypertrophy through releasing TTP-inhibited TFAM.
      Title: NRF1-enhanced miR-4458 alleviates cardiac hypertrophy through releasing TTP-inhibited TFAM.
    7. Identification of microRNA3633p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53signaling pathway.
      Title: Identification of microRNA‑363‑3p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53‑signaling pathway.
    8. NRF1 regulates testosterone synthesis through transcription regulation of Star.
      Title: Transcription regulation of NRF1 on StAR reduces testosterone synthesis in hypoxemic murine.
    9. the present study demonstrated that NRF1 protected against CoCl2induced apoptosis, potentially by strengthening mitochondrial function to resist CoCl2induced damage to H9C2 cells. The results of the present study provide a possible way for the investigation of myocardial diseases.
      Title: Effects of nuclear respiratory factor‑1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells.
    10. Our findings suggest that NRF-1 regulates the expression of CXCR4 in normal retinal development and in pathologic processes of retinal hypoxia and neovascularization.
      Title: Nuclear Respiratory Factor-1 (NRF-1) Regulates Transcription of the CXC Receptor 4 (CXCR4) in the Rat Retina.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to electrical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to folic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear respiratory factor 1
    Names
    NRF-1
    alpha palindromic-binding protein
    alpha-pal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100708.1 → NP_001094178.1  nuclear respiratory factor 1

      See identical proteins and their annotated locations for NP_001094178.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161956
      UniProtKB/TrEMBL
      A6IEF3, B1WC04, F7FCI9
      Related
      ENSRNOP00000094397.1, ENSRNOT00000117472.2
      Conserved Domains (2) summary
      cd04867
      Location:450 → 525
      TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      59632366..59738166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107511.2 → XP_038963439.1  nuclear respiratory factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KA43
      Related
      ENSRNOP00000075252.2, ENSRNOT00000080173.3
      Conserved Domains (2) summary
      pfam10492
      Location:462 → 505
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    2. XM_006236200.5 → XP_006236262.1  nuclear respiratory factor 1 isoform X8

      Related
      ENSRNOP00000079043.1, ENSRNOT00000104816.2
      Conserved Domains (2) summary
      pfam10492
      Location:470 → 523
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    3. XM_006236198.5 → XP_006236260.1  nuclear respiratory factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006236260.1

      UniProtKB/TrEMBL
      A0A8I6ALN8, A6IEF2
      Related
      ENSRNOP00000091041.2, ENSRNOT00000118984.2
      Conserved Domains (2) summary
      pfam10492
      Location:450 → 493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    4. XM_063285983.1 → XP_063142053.1  nuclear respiratory factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KA43

    5. XM_063285984.1 → XP_063142054.1  nuclear respiratory factor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ALN8, A6IEF2

    6. XM_017592611.3 → XP_017448100.1  nuclear respiratory factor 1 isoform X1

      Related
      ENSRNOP00000011851.3, ENSRNOT00000011851.5
      Conserved Domains (2) summary
      cd04867
      Location:462 → 537
      TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
      pfam10491
      Location:87 → 295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    7. XM_017592612.3 → XP_017448101.1  nuclear respiratory factor 1 isoform X1

      Conserved Domains (2) summary
      cd04867
      Location:462 → 537
      TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
      pfam10491
      Location:87 → 295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    8. XM_063285982.1 → XP_063142052.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A6IEF3, B1WC04, F7FCI9

    9. XM_039107513.2 → XP_038963441.1  nuclear respiratory factor 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ALN8
      Conserved Domains (1) summary
      pfam10491
      Location:87 → 295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    10. XM_039107512.2 → XP_038963440.1  nuclear respiratory factor 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ALN8
      Conserved Domains (1) summary
      pfam10491
      Location:87 → 295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    11. XM_039107514.2 → XP_038963442.1  nuclear respiratory factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZWF5, A0A8I6ALN8
      Related
      ENSRNOP00000083755.1, ENSRNOT00000115640.2
      Conserved Domains (1) summary
      pfam10491
      Location:87 → 283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    12. XM_063285985.1 → XP_063142055.1  nuclear respiratory factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZWF5, A0A8I6ALN8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62792.1 GenPept UniProtKB/Swiss-Prot:Q62792

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