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    Zfp638 zinc finger protein 638 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp638provided by RGD
    Official Full Name
    zinc finger protein 638provided by RGD
    Primary source
    RGD:1309746
    See related
    EnsemblRapid:ENSRNOG00000014501 AllianceGenome:RGD:1309746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfml
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZNF638 (zinc finger protein 638). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 281.0), Brain (RPKM 268.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp638 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117913528..118032644)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (116355934..116475051)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (115555185..115690272)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene uncharacterized LOC134486808 Neighboring gene ribosomal protein S15, pseudogene 12 Neighboring gene U4 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA5 Neighboring gene dysferlin Neighboring gene 60S ribosomal protein L31 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 638

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395046.1 → NP_001381975.1  zinc finger protein 638

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D4A0U3
      Related
      ENSRNOP00000089064.2, ENSRNOT00000116644.2
      Conserved Domains (4) summary
      PRK13808
      Location:753 → 882
      PRK13808; adenylate kinase; Provisional
      smart00451
      Location:1870 → 1902
      ZnF_U1; U1-like zinc finger
      smart00360
      Location:678 → 746
      RRM; RNA recognition motif
      TIGR01649
      Location:1005 → 1069
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117913528..118032644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236749.5 → XP_006236811.1  zinc finger protein 638 isoform X1

      UniProtKB/TrEMBL
      D4A0U3
      Conserved Domains (5) summary
      smart00451
      Location:2000 → 2032
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:1101 → 1174
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:997 → 1071
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:998 → 1295
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:772 → 847
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_006236751.5 → XP_006236813.1  zinc finger protein 638 isoform X3

      UniProtKB/TrEMBL
      D4A0U3
      Related
      ENSRNOP00000107552.1, ENSRNOT00000145851.1
      Conserved Domains (5) summary
      smart00451
      Location:1966 → 1998
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:1101 → 1174
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:997 → 1071
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:998 → 1295
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:772 → 847
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_039107597.2 → XP_038963525.1  zinc finger protein 638 isoform X11

      Conserved Domains (4) summary
      PTZ00121
      Location:836 → 995
      PTZ00121; MAEBL; Provisional
      smart00451
      Location:1314 → 1346
      ZnF_U1; U1-like zinc finger
      cd12716
      Location:997 → 1071
      RRM1_2_NP220; RNA recognition motif 1 (RRM1) and 2 (RRM2) found in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772 → 847
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_039107598.2 → XP_038963526.1  zinc finger protein 638 isoform X12

      Conserved Domains (4) summary
      PTZ00121
      Location:836 → 995
      PTZ00121; MAEBL; Provisional
      smart00451
      Location:1280 → 1312
      ZnF_U1; U1-like zinc finger
      cd12716
      Location:997 → 1071
      RRM1_2_NP220; RNA recognition motif 1 (RRM1) and 2 (RRM2) found in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772 → 847
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_039107594.2 → XP_038963522.1  zinc finger protein 638 isoform X4

      UniProtKB/TrEMBL
      D4A0U3
      Conserved Domains (3) summary
      PTZ00121
      Location:847 → 1006
      PTZ00121; MAEBL; Provisional
      smart00451
      Location:1956 → 1988
      ZnF_U1; U1-like zinc finger
      cl17169
      Location:772 → 847
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_006236750.5 → XP_006236812.1  zinc finger protein 638 isoform X2

      UniProtKB/TrEMBL
      D4A0U3
      Conserved Domains (5) summary
      smart00451
      Location:1977 → 2009
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:1078 → 1151
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:974 → 1048
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:975 → 1272
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:772 → 847
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_063286060.1 → XP_063142130.1  zinc finger protein 638 isoform X17

      UniProtKB/TrEMBL
      D4A0U3

    8. XM_006236753.5 → XP_006236815.1  zinc finger protein 638 isoform X5

      UniProtKB/TrEMBL
      D4A0U3
      Conserved Domains (5) summary
      smart00451
      Location:1949 → 1981
      ZnF_U1; U1-like zinc finger
      cd12436
      Location:1050 → 1123
      RRM1_2_MATR3_like; RNA recognition motif 1 and 2 in the matrin 3 family of nuclear proteins
      cd12716
      Location:946 → 1020
      RRM1_2_NP220; RNA recognition motif 1 and 2 in vertebrate nuclear protein 220 (NP220)
      TIGR01649
      Location:947 → 1244
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:772 → 847
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. XM_039107600.2 → XP_038963528.1  zinc finger protein 638 isoform X6

      UniProtKB/TrEMBL
      D4A0U3
      Conserved Domains (3) summary
      smart00451
      Location:1915 → 1947
      ZnF_U1; U1-like zinc finger
      cd12716
      Location:946 → 1020
      RRM1_2_NP220; RNA recognition motif 1 (RRM1) and 2 (RRM2) found in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772 → 847
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. XM_063286059.1 → XP_063142129.1  zinc finger protein 638 isoform X16

    11. XM_039107595.2 → XP_038963523.1  zinc finger protein 638 isoform X7

      UniProtKB/TrEMBL
      D4A0U3
      Conserved Domains (3) summary
      PTZ00121
      Location:1277 → 1885
      PTZ00121; MAEBL; Provisional
      smart00451
      Location:1905 → 1937
      ZnF_U1; U1-like zinc finger
      cl17169
      Location:772 → 847
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. XM_063286058.1 → XP_063142128.1  zinc finger protein 638 isoform X15

    13. XM_039107599.2 → XP_038963527.1  zinc finger protein 638 isoform X13

      Conserved Domains (3) summary
      PTZ00121
      Location:836 → 995
      PTZ00121; MAEBL; Provisional
      cd12716
      Location:997 → 1071
      RRM1_2_NP220; RNA recognition motif 1 (RRM1) and 2 (RRM2) found in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:772 → 847
      RRM_SF; RNA recognition motif (RRM) superfamily

    14. XM_006236754.5 → XP_006236816.1  zinc finger protein 638 isoform X8

      UniProtKB/TrEMBL
      D4A0U3
      Conserved Domains (4) summary
      PTZ00121
      Location:751 → 900
      PTZ00121; MAEBL; Provisional
      smart00451
      Location:1904 → 1936
      ZnF_U1; U1-like zinc finger
      cd12716
      Location:901 → 975
      RRM1_2_NP220; RNA recognition motif 1 (RRM1) and 2 (RRM2) found in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:676 → 751
      RRM_SF; RNA recognition motif (RRM) superfamily

    15. XM_063286056.1 → XP_063142126.1  zinc finger protein 638 isoform X14

    16. XM_039107596.2 → XP_038963524.1  zinc finger protein 638 isoform X8

      UniProtKB/TrEMBL
      D4A0U3
      Conserved Domains (4) summary
      PTZ00121
      Location:751 → 900
      PTZ00121; MAEBL; Provisional
      smart00451
      Location:1904 → 1936
      ZnF_U1; U1-like zinc finger
      cd12716
      Location:901 → 975
      RRM1_2_NP220; RNA recognition motif 1 (RRM1) and 2 (RRM2) found in vertebrate nuclear protein 220 (NP220)
      cl17169
      Location:676 → 751
      RRM_SF; RNA recognition motif (RRM) superfamily

    17. XM_063286054.1 → XP_063142124.1  zinc finger protein 638 isoform X9

      UniProtKB/TrEMBL
      D4A0U3
      Related
      ENSRNOP00000094421.2, ENSRNOT00000109348.2

    18. XM_063286055.1 → XP_063142125.1  zinc finger protein 638 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AN40, D4A0U3
      Related
      ENSRNOP00000019617.6, ENSRNOT00000019617.7

    19. XM_063286057.1 → XP_063142127.1  zinc finger protein 638 isoform X14

    Nucleotide Protein Strain
    Heading Accession and Version

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