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    Golt1b golgi transport 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Golt1bprovided by RGD
    Official Full Name
    golgi transport 1Bprovided by RGD
    Primary source
    RGD:1310691
    See related
    EnsemblRapid:ENSRNOG00000058386 AllianceGenome:RGD:1310691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310691
    Summary
    Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human GOLT1B (golgi transport 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 128.3), Lung (RPKM 123.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Golt1b in Genome Data Viewer
    Location:
    4q44
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177064071..177077165)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175333056..175346156)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176606669..176617884)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549024 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene RecQ like helicase Neighboring gene spexin hormone Neighboring gene glycogen synthase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZMPSTE24 defends against influenza and other pathogenic viruses. Fu B, et al. J Exp Med, 2017 Apr 3. PMID 28246125, Free PMC Article
    2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vesicle transport protein GOT1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113783.1 → NP_001107255.1  vesicle transport protein GOT1B

      See identical proteins and their annotated locations for NP_001107255.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158751
      UniProtKB/TrEMBL
      A6IMT9, B0BNB0
      Related
      ENSRNOP00000092199.1, ENSRNOT00000108416.2
      Conserved Domains (1) summary
      cl02130
      Location:4 → 120
      Got1; Got1/Sft2-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      177064071..177077165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107915.2 → XP_038963843.1  vesicle transport protein GOT1B isoform X3

    2. XM_063286374.1 → XP_063142444.1  vesicle transport protein GOT1B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZME6, A6IMT9

    3. XM_039107914.2 → XP_038963842.1  vesicle transport protein GOT1B isoform X2

      UniProtKB/TrEMBL
      A6IMT9
      Related
      ENSRNOP00000070214.3, ENSRNOT00000084700.3
      Conserved Domains (1) summary
      cl02130
      Location:4 → 120
      Got1; Got1/Sft2-like family
    Nucleotide Protein Strain
    Heading Accession and Version

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