Foxj2 forkhead box J2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxj2provided by RGD
Official Full Name: forkhead box J2provided by RGD
Primary source: RGD:1565101
See related: EnsemblRapid:ENSRNOG00000009000 AllianceGenome:RGD:1565101
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565101
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in several processes, including male meiosis I; negative regulation of blood vessel endothelial cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Orthologous to human FOXJ2 (forkhead box J2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 89.6), Lung (RPKM 66.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (157718990..157745468)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (156047043..156073540)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (155653446..155679815)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXJ2 may be involved in the pathophysiology of spinal cord injuries.
Title: FOXJ2 expression in rat spinal cord after injury and its role in inflammation.

Submit: New GeneRIF Correction

General gene information

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Markers

Foxj2 (e-PCR), detects polymorphism
- UniSTS:506902

D4Got126 (e-PCR)
- UniSTS:111965

RH134938 (e-PCR)
- UniSTS:218215

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in male meiosis I	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein J2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109352.2 → NP_001102822.1 forkhead box protein J2

See identical proteins and their annotated locations for NP_001102822.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6ILG0, D3Z992

Related

ENSRNOP00000062121.1, ENSRNOT00000065419.4

Conserved Domains (1) summary

pfam00250
Location:66 → 143

Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

157718990..157745468

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108257.2 → XP_038964185.1 forkhead box protein J2 isoform X2

Conserved Domains (2) summary

COG5025
Location:33 → 153

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cl00061
Location:105 → 161

FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins
XM_006237311.5 → XP_006237373.1 forkhead box protein J2 isoform X1

UniProtKB/TrEMBL

A0A0G2JW18

Related

ENSRNOP00000069705.1, ENSRNOT00000087883.3

Conserved Domains (1) summary

pfam00250
Location:106 → 183

Forkhead; Forkhead domain