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    Zfp37 zinc finger protein 37 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 115768, updated on 9-Dec-2024

    Summary

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    Symbol
    Zfp37provided by RGD
    Full Name
    zinc finger protein 37provided by RGD
    Primary source
    RGD:620723
    See related
    EnsemblRapid:ENSRNOG00000069865 AllianceGenome:RGD:620723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cell differentiation. Predicted to be active in nucleus. Orthologous to human ZFP37 (ZFP37 zinc finger protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 25.6), Kidney (RPKM 19.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp37 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (80600463..80656064, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (75598732..75638896, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (77829492..77945361, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene major urinary protein-like Neighboring gene major urinary protein 4, pseudogene 5 Neighboring gene transfer RNA proline (anticodon GGG) 4 Neighboring gene RIKEN cDNA 3110040M04 gene like 2 Neighboring gene uncharacterized LOC108350981

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37. Vanden Heuvel JP, et al. Toxicol Appl Pharmacol, 1998 Sep. PMID 9772206
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 37
    Names
    zfp-37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_058209.2 → NP_478116.2  zinc finger protein 37

      Status: VALIDATED

      Source sequence(s)
      BC166844, CB727538
      UniProtKB/TrEMBL
      A0A8I6AAE9
      Related
      ENSRNOP00000089492.2, ENSRNOT00000100489.2
      Conserved Domains (6) summary
      cd07765
      Location:28 → 68
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:41 → 89
      KRAB; krueppel associated box
      COG5048
      Location:124 → 518
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:429 → 449
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:371 → 393
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:385 → 410
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      80600463..80656064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109135.2 → XP_038965063.1  zinc finger protein 37 isoform X2

      UniProtKB/TrEMBL
      A6J7T5
      Conserved Domains (4) summary
      smart00349
      Location:38 → 88
      KRAB; krueppel associated box
      COG5048
      Location:272 → 597
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:428 → 448
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:594 → 616
      zf-C2H2; Zinc finger, C2H2 type

    2. XM_063287064.1 → XP_063143134.1  zinc finger protein 37 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAE9

    3. XM_039109136.2 → XP_038965064.1  zinc finger protein 37 isoform X3

      UniProtKB/TrEMBL
      F1LYQ2
      Related
      ENSRNOP00000053737.5, ENSRNOT00000056900.7
      Conserved Domains (4) summary
      COG5048
      Location:230 → 555
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:386 → 406
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:552 → 574
      zf-C2H2; Zinc finger, C2H2 type
      cl02581
      Location:41 → 69
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    4. XM_039109137.2 → XP_038965065.1  zinc finger protein 37 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:229 → 554
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:385 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:551 → 573
      zf-C2H2; Zinc finger, C2H2 type
      cl02581
      Location:38 → 68
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    5. XM_039109140.2 → XP_038965068.1  zinc finger protein 37 isoform X5

      Conserved Domains (2) summary
      COG5048
      Location:206 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:362 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_039109138.2 → XP_038965066.1  zinc finger protein 37 isoform X5

      Conserved Domains (2) summary
      COG5048
      Location:206 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:362 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_039109139.2 → XP_038965067.1  zinc finger protein 37 isoform X5

      Related
      ENSRNOP00000097307.2, ENSRNOT00000100418.2
      Conserved Domains (2) summary
      COG5048
      Location:206 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:362 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88553.1 GenPept UniProtKB/Swiss-Prot:O88553

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