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    Nin ninein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299117, updated on 9-Dec-2024

    Summary

    Symbol
    Ninprovided by RGD
    Full Name
    nineinprovided by RGD
    Primary source
    RGD:1306492
    See related
    EnsemblRapid:ENSRNOG00000005540 AllianceGenome:RGD:1306492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microtubule minus-end binding activity. Predicted to be involved in centrosome localization; microtubule cytoskeleton organization; and protein localization. Predicted to act upstream of or within axonogenesis and positive regulation of axonogenesis. Predicted to be located in several cellular components, including axonal growth cone; microtubule cytoskeleton; and nuclear lumen. Predicted to be part of centriolar subdistal appendage and ciliary transition fiber. Predicted to be active in centriole; mitotic spindle pole; and pericentriolar material. Human ortholog(s) of this gene implicated in Seckel syndrome 7. Orthologous to human NIN (ninein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 147.7), Spleen (RPKM 142.1) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nin in Genome Data Viewer
    Location:
    6q24
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (94261382..94363679, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88525405..88627710, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92423412..92527776, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene salvador family WW domain containing protein 1 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 5 Neighboring gene abhydrolase domain containing 12B Neighboring gene glycogen phosphorylase L Neighboring gene uncharacterized LOC134479216

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule minus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    part_of centriolar subdistal appendage ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ciliary transition fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ciliary transition fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in pericentriolar material IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ninein
    Names
    ninein (GSK3B interacting protein)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106737.1NP_001100207.1  ninein isoform 1

      See identical proteins and their annotated locations for NP_001100207.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A0A8I6A7B7, A6HBY6
      Conserved Domains (5) summary
      COG1196
      Location:6981573
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16269
      Location:792803
      GBP_C; coiled coil [structural motif]
      cl00459
      Location:377552
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:475567
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:709821
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. NM_001434244.1NP_001421173.1  ninein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
    3. NM_001434245.1NP_001421174.1  ninein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A7B7, D4A1J7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      94261382..94363679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594089.3XP_017449578.1  ninein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7B7
      Conserved Domains (3) summary
      COG1196
      Location:14331672
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:388981
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:10451998
      CCDC158; Coiled-coil domain-containing protein 158
    2. XM_008764706.4XP_008762928.1  ninein isoform X4

      UniProtKB/TrEMBL
      A0A8I6A7B7
      Conserved Domains (5) summary
      COG1196
      Location:6981573
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16269
      Location:792803
      GBP_C; coiled coil [structural motif]
      cl00459
      Location:377552
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:475567
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:709821
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. XM_008764705.4XP_008762927.1  ninein isoform X3

      UniProtKB/TrEMBL
      A0A8I6A538, A0A8I6A7B7
      Related
      ENSRNOP00000088832.2, ENSRNOT00000108786.2
      Conserved Domains (5) summary
      COG1196
      Location:6981573
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:358951
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd16269
      Location:792803
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:475567
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:709821
      GBP_C; Guanylate-binding protein, C-terminal domain
    4. XM_063261705.1XP_063117775.1  ninein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7B7
    5. XM_006240158.5XP_006240220.1  ninein isoform X1

      See identical proteins and their annotated locations for XP_006240220.1

      UniProtKB/TrEMBL
      A0A8I6A7B7
      Conserved Domains (3) summary
      COG1196
      Location:14331672
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:388981
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:10451998
      CCDC158; Coiled-coil domain-containing protein 158
    6. XM_039111992.2XP_038967920.1  ninein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7B7
      Conserved Domains (3) summary
      COG1196
      Location:14331672
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:388981
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:10451998
      CCDC158; Coiled-coil domain-containing protein 158
    7. XM_063261708.1XP_063117778.1  ninein isoform X13

    8. XM_008764710.4XP_008762932.1  ninein isoform X14

      Conserved Domains (5) summary
      TIGR02168
      Location:3541103
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd16269
      Location:792803
      GBP_C; coiled coil [structural motif]
      cl00459
      Location:377552
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:475567
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:709821
      GBP_C; Guanylate-binding protein, C-terminal domain
    9. XM_039111994.2XP_038967922.1  ninein isoform X12

      UniProtKB/TrEMBL
      A0A8I6A5C4
      Conserved Domains (2) summary
      PRK01156
      Location:8331433
      PRK01156; chromosome segregation protein; Provisional
      TIGR02168
      Location:3841128
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    10. XM_063261706.1XP_063117776.1  ninein isoform X6

      UniProtKB/TrEMBL
      A0A8I6A7B7
    11. XM_008764707.4XP_008762929.1  ninein isoform X5

      UniProtKB/TrEMBL
      A0A8I6A7B7
      Conserved Domains (6) summary
      COG1196
      Location:7281603
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:15331985
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd16269
      Location:822833
      GBP_C; coiled coil [structural motif]
      cl00459
      Location:407582
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:505597
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:739851
      GBP_C; Guanylate-binding protein, C-terminal domain
    12. XM_008764708.4XP_008762930.1  ninein isoform X7

      Related
      ENSRNOP00000007529.5, ENSRNOT00000007529.6
      Conserved Domains (6) summary
      COG1196
      Location:6981573
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:15031955
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd16269
      Location:792803
      GBP_C; coiled coil [structural motif]
      cl00459
      Location:377552
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:475567
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:709821
      GBP_C; Guanylate-binding protein, C-terminal domain
    13. XM_063261709.1XP_063117779.1  ninein isoform X15

      Related
      ENSRNOP00000086179.2, ENSRNOT00000112425.2
    14. XM_017594090.3XP_017449579.1  ninein isoform X10

      UniProtKB/TrEMBL
      A0A8I6A7B7
    15. XM_008764709.4XP_008762931.1  ninein isoform X8

      UniProtKB/TrEMBL
      A0A8I6A7B7
      Related
      ENSRNOP00000044897.7, ENSRNOT00000052408.7
      Conserved Domains (6) summary
      COG1196
      Location:7281603
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04523
      Location:15331984
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cd16269
      Location:822833
      GBP_C; coiled coil [structural motif]
      cl00459
      Location:407582
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:505597
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:739851
      GBP_C; Guanylate-binding protein, C-terminal domain
    16. XM_017594091.3XP_017449580.1  ninein isoform X11

      UniProtKB/TrEMBL
      A0A8I6A7B7
    17. XM_039111993.2XP_038967921.1  ninein isoform X9

      UniProtKB/TrEMBL
      A0A8I6A7B7
      Conserved Domains (3) summary
      COG1196
      Location:14331672
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:388981
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:10451982
      CCDC158; Coiled-coil domain-containing protein 158