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    Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arel1provided by RGD
    Official Full Name
    apoptosis resistant E3 ubiquitin protein ligase 1provided by RGD
    Primary source
    RGD:1307597
    See related
    EnsemblRapid:ENSRNOG00000004382 AllianceGenome:RGD:1307597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307597
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Orthologous to human AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 94.0), Kidney (RPKM 86.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arel1 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110296072..110348751, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104560556..104617712, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108630790..108796096, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly 2 Neighboring gene latent transforming growth factor beta binding protein 2 Neighboring gene Fcf1 rRNA-processing protein Neighboring gene eukaryotic translation initiation factor 2 subunit 2-like Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene YLP motif containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. Lear TB, et al. JCI Insight, 2019 Oct 3. PMID 31578312, Free PMC Article
    2. Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. Kim JB, et al. J Biol Chem, 2013 Apr 26. PMID 23479728, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K33-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis-resistant E3 ubiquitin protein ligase 1
    NP_001100214.1
    XP_006240395.1
    XP_008762976.1
    XP_017449586.1
    XP_038967965.1
    XP_038967966.1
    XP_038967967.1
    XP_063117810.1
    XP_063117812.1
    XP_063117813.1
    XP_063117814.1
    XP_063117815.1
    XP_063117816.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106744.1 → NP_001100214.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1

      See identical proteins and their annotated locations for NP_001100214.1

      Status: VALIDATED

      Source sequence(s)
      CH473982
      UniProtKB/TrEMBL
      A6JDZ1, D3ZVC4
      Related
      ENSRNOP00000006240.5, ENSRNOT00000006240.8
      Conserved Domains (2) summary
      smart00119
      Location:486 → 820
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    2. NM_001433934.1 → NP_001420863.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDZ1, D3ZVC4

    3. NM_001433935.1 → NP_001420864.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDZ1, D3ZVC4

    4. NM_001433936.1 → NP_001420865.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDZ1, D3ZVC4

    5. NM_001433937.1 → NP_001420866.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDZ1, D3ZVC4

    6. NM_001433938.1 → NP_001420867.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    7. NM_001433939.1 → NP_001420868.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    8. NM_001433940.1 → NP_001420869.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      110296072..110348751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594097.3 → XP_017449586.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

      Conserved Domains (3) summary
      smart00119
      Location:476 → 810
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:454 → 811
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56 → 144
      Filamin; Filamin/ABP280 repeat

    2. XM_008764754.4 → XP_008762976.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      Conserved Domains (2) summary
      smart00119
      Location:486 → 820
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    3. XM_063261743.1 → XP_063117813.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      UniProtKB/TrEMBL
      A6JDZ1, D3ZVC4

    4. XM_063261742.1 → XP_063117812.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      UniProtKB/TrEMBL
      A6JDZ1, D3ZVC4

    5. XM_039112038.2 → XP_038967966.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      Conserved Domains (2) summary
      smart00119
      Location:486 → 820
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    6. XM_039112037.2 → XP_038967965.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      UniProtKB/TrEMBL
      A6JDZ1, D3ZVC4
      Conserved Domains (2) summary
      smart00119
      Location:486 → 820
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    7. XM_063261744.1 → XP_063117814.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

    8. XM_063261740.1 → XP_063117810.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    9. XM_039112039.2 → XP_038967967.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      Conserved Domains (2) summary
      smart00119
      Location:486 → 820
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    10. XM_063261745.1 → XP_063117815.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

    11. XM_006240333.4 → XP_006240395.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006240395.1

      UniProtKB/TrEMBL
      A6JDZ1, D3ZVC4
      Conserved Domains (2) summary
      smart00119
      Location:486 → 820
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    12. XM_063261746.1 → XP_063117816.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

    RNA

    1. XR_010052071.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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