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    Gpr65 G-protein coupled receptor 65 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr65provided by RGD
    Official Full Name
    G-protein coupled receptor 65provided by RGD
    Primary source
    RGD:1311832
    See related
    EnsemblRapid:ENSRNOG00000065590 AllianceGenome:RGD:1311832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tdag8
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including activation of GTPase activity; positive regulation of stress fiber assembly; and response to acidic pH. Predicted to be active in plasma membrane. Orthologous to human GPR65 (G protein-coupled receptor 65). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 102.0), Thymus (RPKM 89.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr65 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123245534..123262758)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (117515786..117536514)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122248528..122256115)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cofilin 1, pseudogene 1 Neighboring gene uncharacterized LOC120093266 Neighboring gene galactosylceramidase Neighboring gene uncharacterized LOC120103597 Neighboring gene potassium two pore domain channel subfamily K member 10 Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats. Ma XD, et al. Exp Neurol, 2017 Jul. PMID 28365474
    2. Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain. McGuire J, et al. Biochem Biophys Res Commun, 2009 Aug 28. PMID 19501050, Free PMC Article
    3. Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. Ishii S, et al. J Biol Chem, 2005 Mar 11. PMID 15618224
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    psychosine receptor
    Names
    T cell death associated protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106751.3 → NP_001100221.1  psychosine receptor

      See identical proteins and their annotated locations for NP_001100221.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AHC6, B0YIR8
      Related
      ENSRNOP00000078802.1, ENSRNOT00000097200.2
      Conserved Domains (2) summary
      cd14964
      Location:17 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 301
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      123245534..123262758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112062.2 → XP_038967990.1  psychosine receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHC6, B0YIR8
      Related
      ENSRNOP00000105322.1, ENSRNOT00000134563.1
      Conserved Domains (2) summary
      cd14964
      Location:17 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 301
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_008764761.4 → XP_008762983.1  psychosine receptor isoform X1

      See identical proteins and their annotated locations for XP_008762983.1

      UniProtKB/TrEMBL
      A0A8I6AHC6, B0YIR8
      Related
      ENSRNOP00000099482.1, ENSRNOT00000161307.1
      Conserved Domains (2) summary
      cd14964
      Location:17 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 301
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_039112061.2 → XP_038967989.1  psychosine receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHC6, B0YIR8
      Related
      ENSRNOP00000107465.1, ENSRNOT00000169123.1
      Conserved Domains (2) summary
      cd14964
      Location:17 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 301
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_039112063.2 → XP_038967991.1  psychosine receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHC6, B0YIR8
      Related
      ENSRNOP00000107635.1, ENSRNOT00000139166.1
      Conserved Domains (2) summary
      cd14964
      Location:17 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 301
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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