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    Grhl1 grainyhead-like transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313993, updated on 9-Dec-2024

    Summary

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    Symbol
    Grhl1provided by RGD
    Full Name
    grainyhead-like transcription factor 1provided by RGD
    Primary source
    RGD:1305735
    See related
    EnsemblRapid:ENSRNOG00000054989 AllianceGenome:RGD:1305735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and protein homodimerization activity. Predicted to be involved in epidermis development and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including desmosome organization; establishment of skin barrier; and regulation of keratinocyte differentiation. Predicted to be located in nucleoplasm. Orthologous to human GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 23.6), Testes (RPKM 21.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Grhl1 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (46935947..46986126)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (41207325..41257516)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (43734837..43795757)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479119 Neighboring gene uncharacterized LOC134479120 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit B Neighboring gene RNA binding motif protein 34, pseudogene 1 Neighboring gene KLF transcription factor 11 Neighboring gene cystin 1 Neighboring gene ribonucleotide reductase regulatory subunit M2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin. Mlacki M, et al. PLoS One, 2014. PMID 24586629, Free PMC Article
    2. Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family. Ming Q, et al. Nucleic Acids Res, 2018 Feb 28. PMID 29309642, Free PMC Article
    3. Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. Wilanowski T, et al. EMBO J, 2008 Mar 19. PMID 18288204, Free PMC Article
    4. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Wilanowski T, et al. Mech Dev, 2002 Jun. PMID 12175488
    5. The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Boglev Y, et al. Dev Biol, 2011 Jan 15. PMID 21081122

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within desmosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of skin barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    grainyhead-like protein 1 homolog
    Names
    DNA methyltransferase 3A
    grainyhead-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431901.1 → NP_001418830.1  grainyhead-like protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2JTY1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      46935947..46986126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113151.2 → XP_038969079.1  grainyhead-like protein 1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTY1
      Conserved Domains (1) summary
      pfam04516
      Location:235 → 440
      CP2; CP2 transcription factor

    2. XM_234006.11 → XP_234006.5  grainyhead-like protein 1 homolog isoform X1

      Related
      ENSRNOP00000068887.3, ENSRNOT00000082570.3
      Conserved Domains (1) summary
      pfam04516
      Location:235 → 440
      CP2; CP2 transcription factor

    3. XM_063262748.1 → XP_063118818.1  grainyhead-like protein 1 homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTY1

    4. XM_063262749.1 → XP_063118819.1  grainyhead-like protein 1 homolog isoform X3

      UniProtKB/TrEMBL
      A0A0G2JTY1

    RNA

    1. XR_010052540.1 RNA Sequence

    2. XR_010052541.1 RNA Sequence

    3. XR_010052542.1 RNA Sequence

    4. XR_010052543.1 RNA Sequence

    5. XR_010052544.1 RNA Sequence

    6. XR_010052546.1 RNA Sequence

    7. XR_010052545.1 RNA Sequence

    8. XR_010052547.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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