Kif21a kinesin family member 21A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif21aprovided by RGD
Official Full Name: kinesin family member 21Aprovided by RGD
Primary source: RGD:1305126
See related: EnsemblRapid:ENSRNOG00000014844 AllianceGenome:RGD:1305126
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP hydrolysis activity; ankyrin repeat binding activity; and plus-end-directed microtubule motor activity. Involved in anterograde axonal transport. Is active in presynapse. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 1. Orthologous to human KIF21A (kinesin family member 21A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 220.6), Kidney (RPKM 137.9) and 6 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7q35

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (123942079..124058594, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (122062523..122179051, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (132069962..132200947, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

BE115225 (e-PCR)
- UniSTS:248130

BE115241 (e-PCR)
- UniSTS:261456

ECD03969 (e-PCR)
- UniSTS:285049

BE107582 (e-PCR)
- UniSTS:246928

BE120060 (e-PCR)
- UniSTS:247235

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ankyrin repeat binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biological_process	ND No biological Data available more info
involved_in cortical microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axon guidance	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: kinesin-like protein KIF21A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001371538.1 → NP_001358467.1 kinesin-like protein KIF21A

Status: VALIDATED

Source sequence(s)

FQ096185, JAXUCZ010000007

UniProtKB/TrEMBL

D3ZCG2, D3ZYN2

Related

ENSRNOP00000031911.6, ENSRNOT00000038946.9

Conserved Domains (5) summary

pfam05483
Location:642 → 1040

SCP-1; Synaptonemal complex protein 1 (SCP-1)

COG1196
Location:381 → 779

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00200
Location:1337 → 1650

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1388 → 1447

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

123942079..124058594 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263363.1 → XP_063119433.1 kinesin-like protein KIF21A isoform X22

UniProtKB/TrEMBL

D3ZJJ7
XM_063263362.1 → XP_063119432.1 kinesin-like protein KIF21A isoform X21

UniProtKB/TrEMBL

D3ZJJ7
XM_063263354.1 → XP_063119424.1 kinesin-like protein KIF21A isoform X11

UniProtKB/TrEMBL

A0A8I6AEJ5, A0A8I6AMC6

Related

ENSRNOP00000092894.2, ENSRNOT00000110235.2
XM_063263359.1 → XP_063119429.1 kinesin-like protein KIF21A isoform X18

UniProtKB/TrEMBL

D3ZJJ7, D4A1V5

Related

ENSRNOP00000040915.5, ENSRNOT00000046744.7
XM_063263349.1 → XP_063119419.1 kinesin-like protein KIF21A isoform X4

UniProtKB/TrEMBL

A0A8I6A1X3

Related

ENSRNOP00000085651.2, ENSRNOT00000119582.2
XM_039078881.2 → XP_038934809.1 kinesin-like protein KIF21A isoform X1

UniProtKB/TrEMBL

D3ZYN2

Conserved Domains (6) summary

COG0419
Location:344 → 1026

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd00200
Location:1342 → 1655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

TIGR02168
Location:645 → 848

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1393 → 1452

7WD40; WD40 repeat [structural motif]

cd22263
Location:938 → 1019

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
XM_063263352.1 → XP_063119422.1 kinesin-like protein KIF21A isoform X7

UniProtKB/TrEMBL

D3ZYN2

Related

ENSRNOP00000052600.4, ENSRNOT00000055742.6
XM_063263351.1 → XP_063119421.1 kinesin-like protein KIF21A isoform X6

UniProtKB/TrEMBL

D3ZYN2
XM_063263348.1 → XP_063119418.1 kinesin-like protein KIF21A isoform X3

UniProtKB/TrEMBL

D3ZYN2

Related

ENSRNOP00000044677.4, ENSRNOT00000044092.7
XM_063263353.1 → XP_063119423.1 kinesin-like protein KIF21A isoform X10

UniProtKB/TrEMBL

D3ZYN2
XM_039078882.2 → XP_038934810.1 kinesin-like protein KIF21A isoform X2

UniProtKB/TrEMBL

D3ZYN2

Conserved Domains (6) summary

COG0419
Location:348 → 1030

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd00200
Location:1341 → 1654

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

TIGR02168
Location:649 → 852

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01372
Location:18 → 376

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1392 → 1451

7WD40; WD40 repeat [structural motif]

cd22263
Location:942 → 1023

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
XM_063263350.1 → XP_063119420.1 kinesin-like protein KIF21A isoform X5

UniProtKB/TrEMBL

D3ZYN2
XM_063263358.1 → XP_063119428.1 kinesin-like protein KIF21A isoform X16

UniProtKB/TrEMBL

D3ZYN2
XM_039078888.2 → XP_038934816.1 kinesin-like protein KIF21A isoform X9

UniProtKB/TrEMBL

A0A8I6AMC6

Conserved Domains (6) summary

COG1196
Location:385 → 770

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK03918
Location:633 → 1016

PRK03918; DNA double-strand break repair ATPase Rad50

cd00200
Location:1308 → 1621

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:18 → 376

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1359 → 1418

7WD40; WD40 repeat [structural motif]

cd22263
Location:929 → 1010

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
XM_063263365.1 → XP_063119435.1 kinesin-like protein KIF21A isoform X26

UniProtKB/TrEMBL

D3ZJJ7
XM_063263357.1 → XP_063119427.1 kinesin-like protein KIF21A isoform X15

UniProtKB/TrEMBL

D3ZYN2
XM_063263361.1 → XP_063119431.1 kinesin-like protein KIF21A isoform X20

UniProtKB/TrEMBL

D3ZJJ7
XM_063263355.1 → XP_063119425.1 kinesin-like protein KIF21A isoform X12

UniProtKB/TrEMBL

D3ZYN2
XM_039078898.2 → XP_038934826.1 kinesin-like protein KIF21A isoform X25

UniProtKB/TrEMBL

D3ZJJ7

Conserved Domains (6) summary

COG1196
Location:385 → 770

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK03918
Location:633 → 1016

PRK03918; DNA double-strand break repair ATPase Rad50

cd00200
Location:1242 → 1555

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:18 → 376

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1293 → 1352

7WD40; WD40 repeat [structural motif]

cd22263
Location:929 → 1010

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
XM_039078887.2 → XP_038934815.1 kinesin-like protein KIF21A isoform X8

UniProtKB/TrEMBL

A0A8I6A1X3

Conserved Domains (6) summary

COG1196
Location:385 → 770

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK03918
Location:633 → 1016

PRK03918; DNA double-strand break repair ATPase Rad50

cd00200
Location:1315 → 1628

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:18 → 376

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1366 → 1425

7WD40; WD40 repeat [structural motif]

cd22263
Location:929 → 1010

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
XM_063263364.1 → XP_063119434.1 kinesin-like protein KIF21A isoform X24

UniProtKB/TrEMBL

D3ZJJ7
XM_063263356.1 → XP_063119426.1 kinesin-like protein KIF21A isoform X14

UniProtKB/TrEMBL

D3ZYN2
XM_063263366.1 → XP_063119436.1 kinesin-like protein KIF21A isoform X28

UniProtKB/TrEMBL

D3ZJJ7
XM_063263360.1 → XP_063119430.1 kinesin-like protein KIF21A isoform X19

UniProtKB/TrEMBL

D3ZJJ7
XM_039078896.2 → XP_038934824.1 kinesin-like protein KIF21A isoform X23

UniProtKB/TrEMBL

D3ZJJ7

Conserved Domains (6) summary

COG1196
Location:385 → 770

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK03918
Location:633 → 1016

PRK03918; DNA double-strand break repair ATPase Rad50

cd00200
Location:1249 → 1562

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:18 → 376

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1300 → 1359

7WD40; WD40 repeat [structural motif]

cd22263
Location:929 → 1010

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
XM_039078892.2 → XP_038934820.1 kinesin-like protein KIF21A isoform X13

UniProtKB/TrEMBL

D3ZSN6

Conserved Domains (6) summary

COG0419
Location:348 → 1017

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd00200
Location:1285 → 1598

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

TIGR02168
Location:636 → 839

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01372
Location:18 → 376

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1336 → 1395

7WD40; WD40 repeat [structural motif]

cd22263
Location:929 → 1010

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
XM_039078899.2 → XP_038934827.1 kinesin-like protein KIF21A isoform X27

UniProtKB/TrEMBL

D3ZJJ7

Conserved Domains (6) summary

COG1196
Location:385 → 770

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK03918
Location:633 → 1016

PRK03918; DNA double-strand break repair ATPase Rad50

cd00200
Location:1236 → 1549

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:18 → 376

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1287 → 1346

7WD40; WD40 repeat [structural motif]

cd22263
Location:929 → 1010

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
XM_039078893.2 → XP_038934821.1 kinesin-like protein KIF21A isoform X17

UniProtKB/TrEMBL

D3ZJJ7

Conserved Domains (6) summary

COG0419
Location:348 → 1017

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd00200
Location:1272 → 1585

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

TIGR02168
Location:636 → 839

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01372
Location:18 → 376

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1323 → 1382

7WD40; WD40 repeat [structural motif]

cd22263
Location:929 → 1010

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106790.1: Suppressed sequence

Description

NM_001106790.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: KIF21A (GeneID:55605).