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    Nav3 neuron navigator 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314814, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nav3provided by RGD
    Official Full Name
    neuron navigator 3provided by RGD
    Primary source
    RGD:1306259
    See related
    EnsemblRapid:ENSRNOG00000052157 AllianceGenome:RGD:1306259
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306259
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in negative regulation of cell migration; negative regulation of interleukin-2 production; and regulation of microtubule polymerization or depolymerization. Predicted to be located in microtubule end and nuclear envelope. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human NAV3 (neuron navigator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 192.7), Heart (RPKM 102.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nav3 in Genome Data Viewer
    Location:
    7q21
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (46938577..47726839, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (45052206..45840471, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (52164805..52508145, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093800 Neighboring gene Histone deacetylase 1, pseudogene 6 Neighboring gene uncharacterized LOC120093801 Neighboring gene uncharacterized LOC134479685 Neighboring gene E2F transcription factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. Karenko L, et al. Cancer Res, 2005 Sep 15. PMID 16166283
    2. Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression. Cohen-Dvashi H, et al. EMBO Mol Med, 2015 Mar. PMID 25678558, Free PMC Article
    3. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. Coy JF, et al. Gene, 2002 May 15. PMID 12062803
    4. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, et al. Hum Genet, 2008 Jun. PMID 18438686, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in microtubule end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neuron navigator 3
    Names
    pore membrane and/or filament interacting like protein 1
    steerin 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191782.1 → NP_001178711.1  neuron navigator 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JZB7, A0A8I6AR69
      Related
      ENSRNOP00000070987.2, ENSRNOT00000082100.3
      Conserved Domains (5) summary
      cd00009
      Location:2001 → 2081
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:1998 → 2118
      AAA; ATPases associated with a variety of cellular activities
      cd00014
      Location:81 → 182
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15898
      Location:1743 → 1806
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl21455
      Location:1985 → 2015
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      46938577..47726839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263475.1 → XP_063119545.1  neuron navigator 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AFJ1
      Related
      ENSRNOP00000079901.2, ENSRNOT00000097268.2

    2. XM_039079115.2 → XP_038935043.1  neuron navigator 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AFJ1
      Conserved Domains (4) summary
      smart00382
      Location:1999 → 2119
      AAA; ATPases associated with a variety of cellular activities
      COG1196
      Location:1545 → 1805
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:176 → 554
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd21286
      Location:53 → 155
      CH_NAV3; calponin homology (CH) domain found in neuron navigator 3

    3. XM_063263477.1 → XP_063119547.1  neuron navigator 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZLL1

    4. XM_039079114.2 → XP_038935042.1  neuron navigator 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AFJ1
      Conserved Domains (4) summary
      smart00382
      Location:1999 → 2119
      AAA; ATPases associated with a variety of cellular activities
      COG1196
      Location:1545 → 1805
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:176 → 554
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd21286
      Location:53 → 155
      CH_NAV3; calponin homology (CH) domain found in neuron navigator 3

    5. XM_039079110.2 → XP_038935038.1  neuron navigator 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANV3, A0A8I6AR69
      Conserved Domains (4) summary
      smart00382
      Location:2027 → 2147
      AAA; ATPases associated with a variety of cellular activities
      COG1196
      Location:1573 → 1833
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:204 → 582
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd21286
      Location:79 → 183
      CH_NAV3; calponin homology (CH) domain found in neuron navigator 3

    6. XM_039079109.2 → XP_038935037.1  neuron navigator 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANV3, A0A8I6AR69
      Related
      ENSRNOP00000095548.1, ENSRNOT00000119636.2
      Conserved Domains (4) summary
      smart00382
      Location:2027 → 2147
      AAA; ATPases associated with a variety of cellular activities
      COG1196
      Location:1573 → 1833
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:204 → 582
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd21286
      Location:79 → 183
      CH_NAV3; calponin homology (CH) domain found in neuron navigator 3

    7. XM_039079112.2 → XP_038935040.1  neuron navigator 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AR69
      Conserved Domains (4) summary
      smart00382
      Location:2013 → 2133
      AAA; ATPases associated with a variety of cellular activities
      COG1196
      Location:1559 → 1819
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:204 → 582
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd21286
      Location:79 → 183
      CH_NAV3; calponin homology (CH) domain found in neuron navigator 3

    8. XM_039079113.2 → XP_038935041.1  neuron navigator 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AR69
      Conserved Domains (4) summary
      smart00382
      Location:2004 → 2124
      AAA; ATPases associated with a variety of cellular activities
      COG1196
      Location:1550 → 1810
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:225 → 559
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd21286
      Location:79 → 183
      CH_NAV3; calponin homology (CH) domain found in neuron navigator 3

    9. XM_039079111.2 → XP_038935039.1  neuron navigator 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AR69
      Related
      ENSRNOP00000107059.1, ENSRNOT00000171265.1
      Conserved Domains (3) summary
      smart00382
      Location:2020 → 2140
      AAA; ATPases associated with a variety of cellular activities
      pfam05109
      Location:204 → 582
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd21286
      Location:79 → 183
      CH_NAV3; calponin homology (CH) domain found in neuron navigator 3

    10. XM_039079118.2 → XP_038935046.1  neuron navigator 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZNK3
      Conserved Domains (4) summary
      smart00382
      Location:1890 → 2010
      AAA; ATPases associated with a variety of cellular activities
      COG1196
      Location:1436 → 1696
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:67 → 445
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl00030
      Location:1 → 46
      CH_SF; calponin homology (CH) domain superfamily

    11. XM_039079116.2 → XP_038935044.1  neuron navigator 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZNK3
      Conserved Domains (4) summary
      smart00382
      Location:1970 → 2090
      AAA; ATPases associated with a variety of cellular activities
      COG1196
      Location:1516 → 1776
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:147 → 525
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl00030
      Location:25 → 126
      CH_SF; calponin homology (CH) domain superfamily

    12. XM_039079117.2 → XP_038935045.1  neuron navigator 3 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZNK3
      Conserved Domains (4) summary
      smart00382
      Location:1947 → 2067
      AAA; ATPases associated with a variety of cellular activities
      COG1196
      Location:1493 → 1753
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05109
      Location:124 → 502
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl00030
      Location:2 → 103
      CH_SF; calponin homology (CH) domain superfamily

    13. XM_063263478.1 → XP_063119548.1  neuron navigator 3 isoform X11

      UniProtKB/TrEMBL
      A6IGE3

    14. XM_039079119.2 → XP_038935047.1  neuron navigator 3 isoform X10

      UniProtKB/TrEMBL
      A6IGE3
      Conserved Domains (2) summary
      smart00382
      Location:1526 → 1646
      AAA; ATPases associated with a variety of cellular activities
      COG1196
      Location:1072 → 1332
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    15. XM_063263479.1 → XP_063119549.1  neuron navigator 3 isoform X12

      UniProtKB/TrEMBL
      A0A8I6A0K3, A6IGE3
      Related
      ENSRNOP00000084644.1, ENSRNOT00000114741.2
    Nucleotide Protein Strain
    Heading Accession and Version

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