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    St6gal2 ST6 beta-galactoside alpha-2,6-sialyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St6gal2provided by RGD
    Official Full Name
    ST6 beta-galactoside alpha-2,6-sialyltransferase 2provided by RGD
    Primary source
    RGD:1559663
    See related
    EnsemblRapid:ENSRNOG00000046515 AllianceGenome:RGD:1559663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ST6GalII; ST6Gal-II
    Summary
    Predicted to enable beta-galactoside alpha-2,6-sialyltransferase activity. Predicted to be involved in oligosaccharide metabolic process and sialylation. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Orthologous to human ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 43.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See St6gal2 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (9508928..9606900)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (9181744..9274161)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (6966291..7060499)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27A like 9 Neighboring gene heterogeneous nuclear ribonucleoprotein D, pseudogene 2 Neighboring gene vomeronasal 2 receptor, 76 Neighboring gene SIK family kinase 3, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the second type of human beta-galactoside alpha 2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta 1,4GlcNAc structures on oligosaccharides preferentially. Genomic analysis of human sialyltransferase genes. Takashima S, et al. J Biol Chem, 2002 Nov 29. PMID 12235148
    2. Comparison of the enzymatic properties of mouse beta-galactoside alpha2,6-sialyltransferases, ST6Gal I and II. Takashima S, et al. J Biochem, 2003 Aug. PMID 12966079
    3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside alpha-2,6-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-galactoside alpha-2,6-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligosaccharide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-galactoside alpha-2,6-sialyltransferase 2
    Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
    ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
    ST6Gal II
    alpha 2,6-ST 2
    NP_001094358.1
    XP_006244322.1
    XP_006244326.1
    XP_038939078.1
    XP_063122902.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100888.1 → NP_001094358.1  beta-galactoside alpha-2,6-sialyltransferase 2

      See identical proteins and their annotated locations for NP_001094358.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q701R3
      Related
      ENSRNOP00000067395.2, ENSRNOT00000072796.4
      Conserved Domains (1) summary
      pfam00777
      Location:277 → 507
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      9508928..9606900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266832.1 → XP_063122902.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q701R3

    2. XM_039083150.2 → XP_038939078.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q701R3
      Conserved Domains (1) summary
      pfam00777
      Location:277 → 507
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_006244260.5 → XP_006244322.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006244322.1

      UniProtKB/Swiss-Prot
      Q701R3
      Related
      ENSRNOP00000103643.1, ENSRNOT00000158020.1
      Conserved Domains (1) summary
      pfam00777
      Location:277 → 507
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_006244264.5 → XP_006244326.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006244326.1

      UniProtKB/Swiss-Prot
      Q701R3
      Conserved Domains (1) summary
      pfam00777
      Location:277 → 507
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. XR_005488860.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q701R3.1 GenPept UniProtKB/Swiss-Prot:Q701R3

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