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    Slc6a14 solute carrier family 6 member 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298340, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc6a14provided by RGD
    Official Full Name
    solute carrier family 6 member 14provided by RGD
    Primary source
    RGD:1561810
    See related
    EnsemblRapid:ENSRNOG00000005687 AllianceGenome:RGD:1561810
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atb0+
    Summary
    Predicted to enable (R)-carnitine transmembrane transporter activity; carboxylic acid transmembrane transporter activity; and neutral, basic amino acid:sodium:chloride symporter activity. Predicted to be involved in several processes, including (R)-carnitine transmembrane transport; neutral amino acid transport; and sodium ion transmembrane transport. Located in brush border membrane. Biomarker of inflammatory bowel disease. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SLC6A14 (solute carrier family 6 member 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 253.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc6a14 in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (117109063..117169522)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (112314643..112375412)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (120624522..120647964)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sorbitol dehydrogenase, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene SIN3-HDAC complex associated factor, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein kinase C restricts transport of carnitine by amino acid transporter ATB(0,+) apically localized in the blood-brain barrier. Michalec K, et al. Arch Biochem Biophys, 2014 Jul 15. PMID 24823859
    2. Protein kinase C regulates amino acid transporter ATB(0,+). Samluk L, et al. Biochem Biophys Res Commun, 2012 May 25. PMID 22561015
    3. Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes. Uchiyama T, et al. J Cell Physiol, 2008 Mar. PMID 17960566
    4. Stimulation of expression of the intestinal glutamine transporter ATB0 in tumor-bearing rats. Choudry HA, et al. Ann Surg Oncol, 2006 Dec. PMID 17006743
    5. Stimulation of intestinal glutamine absorption in chronic metabolic acidosis. Pan M, et al. Surgery, 2004 Aug. PMID 15300171

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The analyses of brain slices demonstrated ATB(0,+) luminal localization in brain capillaries, confirmed by biotinylation experiments in an in vitro model of the blood-brain barrier.
      Title: Protein kinase C restricts transport of carnitine by amino acid transporter ATB(0,+) apically localized in the blood-brain barrier.
    2. The observed regulation of ATB(0,+) by PKC correlates with high activity of both proteins reported for cancer cells.
      Title: Protein kinase C regulates amino acid transporter ATB(0,+).
    3. Rat pneumocytes express ATB(0,+), which may partly contribute towards recovering cationic and neutral amino acids from alveolar luminal fluid.
      Title: Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes.
    4. The role of carnitine in inflammatory bowel disease (IBD)was evaluated using the expression of the carnitine transporters OCTN2 and ATB0+, and butyrate metabolism in colonocytes in a rat model of IBD.
      Title: Experimental colitis: decreased Octn2 and Atb0+ expression in rat colonocytes induces carnitine depletion that is reversible by carnitine-loaded liposomes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (R)-carnitine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables (R)-carnitine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alanine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aromatic amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-alanine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-alanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables branched-chain amino acid:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables branched-chain amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neutral, basic amino acid:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neutral, basic amino acid:sodium:chloride symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in (R)-carnitine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in (R)-carnitine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in alanine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aromatic amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in beta-alanine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in beta-alanine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in branched-chain amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
    Names
    colonic system B0+ amino acid transporter
    neutral cationic amino acid transporter B0,+
    solute carrier family 6 (amino acid transporter), member 14
    solute carrier family 6 (neurotransmitter transporter), member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037544.2 → NP_001032633.1  sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

      See identical proteins and their annotated locations for NP_001032633.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6GLX0, Q334I2
      Related
      ENSRNOP00000007967.5, ENSRNOT00000007967.8
      Conserved Domains (1) summary
      cd11501
      Location:36 → 639
      SLC6sbd_ATB0; Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      117109063..117169522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099573.2 → XP_038955501.1  sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5L0, A0A8I6GLX0
      Related
      ENSRNOP00000087988.1, ENSRNOT00000115597.2
      Conserved Domains (1) summary
      cd11501
      Location:42 → 645
      SLC6sbd_ATB0; Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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