Mindy4 MINDY lysine 48 deubiquitinase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mindy4provided by RGD
Official Full Name: MINDY lysine 48 deubiquitinase 4provided by RGD
Primary source: RGD:1562590
See related: EnsemblRapid:ENSRNOG00000011530 AllianceGenome:RGD:1562590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam188b; RGD1562590
Summary: Predicted to enable K48-linked deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination and proteolysis. Orthologous to human MINDY4 (MINDY lysine 48 deubiquitinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 37.9), Kidney (RPKM 33.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (85689049..85797553)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (84358660..84469189)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (85427741..85536264)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein K48-linked deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MINDY lysine 48 deubiquitinase 4; probable ubiquitin carboxyl-terminal hydrolase MINDY-4

Names: family with sequence similarity 188, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431721.1 → NP_001418650.1 MINDY lysine 48 deubiquitinase 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

D3ZJJ0

RNA

NR_197244.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

85689049..85797553

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_231787.10 → XP_231787.5 probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X2

Related

ENSRNOP00000015469.7, ENSRNOT00000015469.10

Conserved Domains (1) summary

pfam13898
Location:415 → 751

DUF4205; Domain of unknown function (DUF4205)
XM_039108680.2 → XP_038964608.1 probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X1

Conserved Domains (1) summary

pfam13898
Location:483 → 819

DUF4205; Domain of unknown function (DUF4205)
XM_063286962.1 → XP_063143032.1 probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X4
XM_039108681.2 → XP_038964609.1 probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X3

Conserved Domains (1) summary

pfam13898
Location:85 → 421

DUF4205; Domain of unknown function (DUF4205)