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    Dpy30 dpy-30 histone methyltransferase complex regulatory subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286897, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dpy30provided by RGD
    Official Full Name
    dpy-30 histone methyltransferase complex regulatory subunitprovided by RGD
    Primary source
    RGD:708575
    See related
    EnsemblRapid:ENSRNOG00000027126 AllianceGenome:RGD:708575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aip1
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in endosomal transport and transcription initiation-coupled chromatin remodeling. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. Orthologous to human DPY30 (dpy-30 histone methyltransferase complex regulatory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 280.6), Thymus (RPKM 273.4) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dpy30 in Genome Data Viewer
    Location:
    6q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (26872812..26893580)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (21120947..21141720)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (22296128..22316894)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692563 Neighboring gene spastin Neighboring gene ribosomal protein L18A, pseudogene 5 Neighboring gene uncharacterized LOC120103480 Neighboring gene mediator of cell motility 1 Neighboring gene small nuclear ribonucleoprotein Sm D2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL1/2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Set1C/COMPASS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone methyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein dpy-30 homolog
    Names
    dpy-30 homolog
    dpy-30-like protein
    dpy-30L
    protein rAIP1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170545.1NP_001164016.1  protein dpy-30 homolog

      See identical proteins and their annotated locations for NP_001164016.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BP474453, FM121127
      UniProtKB/Swiss-Prot
      Q8K3E7
      UniProtKB/TrEMBL
      A6H9Y8
      Related
      ENSRNOP00000110515.1, ENSRNOT00000156805.1
      Conserved Domains (1) summary
      pfam05186
      Location:5293
      Dpy-30; Dpy-30 motif
    2. NM_173117.2NP_775140.2  protein dpy-30 homolog

      See identical proteins and their annotated locations for NP_775140.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY129401, BP474453
      UniProtKB/Swiss-Prot
      Q8K3E7
      UniProtKB/TrEMBL
      A6H9Y8
      Conserved Domains (1) summary
      pfam05186
      Location:5293
      Dpy-30; Dpy-30 motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      26872812..26893580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)