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    Sult2a1 sulfotransferase family 2A member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24912, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sult2a1provided by RGD
    Official Full Name
    sulfotransferase family 2A member 1provided by RGD
    Primary source
    RGD:621337
    See related
    EnsemblRapid:ENSRNOG00000078002 AllianceGenome:RGD:621337
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    STa; St2; Sth2; Smp-2; St2a1
    Summary
    Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity and alcohol sulfotransferase activity. Involved in several processes, including cellular response to vitamin D; response to activity; and sulfation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 6959.5) See more
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    Genomic context

    See Sult2a1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (84582011..84639001, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (75451178..75508113, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (76558721..76614315, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene nucleolin, pseudogene 3 Neighboring gene alcohol sulfotransferase-like Neighboring gene U6 spliceosomal RNA Neighboring gene signal recognition particle 72, pseudogene 1 Neighboring gene nucleolin, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA glycine (anticodon ACC) 2 Neighboring gene sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate binding PubMed 
    enables 3'-phosphoadenosine 5'-phosphosulfate binding  
    enables 3'-phosphoadenosine 5'-phosphosulfate binding  
    enables alcohol sulfotransferase activity PubMed 
    enables alcohol sulfotransferase activity  
    enables alcohol sulfotransferase activity  
    enables bile-salt sulfotransferase activity  
    enables bile-salt sulfotransferase activity  
    enables steroid sulfotransferase activity  
    enables steroid sulfotransferase activity  
    enables sulfotransferase activity  
    enables sulfotransferase activity PubMed 
    enables sulfotransferase activity  
    enables sulfotransferase activity  
    enables transferase activity PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process  
    involved_in cellular response to vitamin D PubMed 
    involved_in cholesterol metabolic process  
    involved_in cholesterol metabolic process  
    involved_in ethanol catabolic process  
    involved_in response to activity PubMed 
    involved_in response to insecticide PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in steroid metabolic process PubMed 
    involved_in steroid metabolic process  
    involved_in steroid metabolic process  
    involved_in steroid metabolic process  
    involved_in sulfation  
    involved_in sulfation PubMed 
    acts_upstream_of_or_within sulfation  
    involved_in sulfation  
    involved_in thyroid hormone metabolic process  
    involved_in xenobiotic metabolic process PubMed 
    involved_in xenobiotic metabolic process  
    involved_in xenobiotic metabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  

    General protein information

    Preferred Names
    sulfotransferase 2A1
    Names
    ST
    ST-20
    alcohol sulfotransferase
    bile salt sulfotransferase
    bile-salt sulfotransferase 2A1
    hydroxysteroid sulfotransferase a
    hydroxysteroid sulfotransferase-like
    sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
    sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1
    sulfotransferase hydroxysteroid gene 2
    sulfotransferase, hydroxysteroid preferring 2
    NP_571978.1
    XP_063137138.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131903.1NP_571978.1  sulfotransferase 2A1

      See identical proteins and their annotated locations for NP_571978.1

      Status: PROVISIONAL

      Source sequence(s)
      D14987
      UniProtKB/TrEMBL
      A0A8L2R491
      Related
      ENSRNOP00000070596.2, ENSRNOT00000089371.3
      Conserved Domains (1) summary
      pfam00685
      Location:33277
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      84582011..84639001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281068.1XP_063137138.1  sulfotransferase 2A1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R491

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