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    Rabggtb Rab geranylgeranyltransferase subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rabggtbprovided by RGD
    Official Full Name
    Rab geranylgeranyltransferase subunit betaprovided by RGD
    Primary source
    RGD:3530
    See related
    EnsemblRapid:ENSRNOG00000009992 AllianceGenome:RGD:3530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including Rab geranylgeranyltransferase activity; small GTPase binding activity; and zinc ion binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 515.3), Muscle (RPKM 394.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rabggtb in Genome Data Viewer
    Location:
    2q45
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (245504586..245510878, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (242844758..242850951, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (260110309..260115574, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 17 Neighboring gene mutS homolog 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene small nucleolar RNA, C/D box 45A Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene acyl-CoA dehydrogenase medium chain Neighboring gene small nucleolar RNA SNORA15 Neighboring gene uncharacterized LOC134485696

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells. Arora DK, et al. Islets, 2012 Sep-Oct. PMID 23114750, Free PMC Article
    2. Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Guo Z, et al. Angew Chem Int Ed Engl, 2008. PMID 18399557
    3. Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution. Zhang H, et al. Structure, 2000 Mar 15. PMID 10745007
    4. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. Guo Z, et al. EMBO J, 2008 Sep 17. PMID 18756270, Free PMC Article
    5. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. Armstrong SA, et al. J Biol Chem, 1993 Jun 5. PMID 8505342

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Rab geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Rab geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoprenoid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein geranylgeranylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rab-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rab-protein geranylgeranyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    geranylgeranyl transferase type-2 subunit beta
    Names
    GGTase-II-beta
    Rab geranylgeranyl transferase componenet, subunit beta
    Rab geranylgeranyltransferase, beta subunit
    geranylgeranyl transferase type II subunit beta
    rab GG transferase beta
    rab GGTase beta
    rab geranyl-geranyltransferase subunit beta
    type II protein geranyl-geranyltransferase subunit beta
    NP_619715.2
    XP_063137436.1
    XP_063137437.1
    XP_063137438.1
    XP_063137439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138708.3 → NP_619715.2  geranylgeranyl transferase type-2 subunit beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q08603
      UniProtKB/TrEMBL
      A0A8I6GFF2, A6HWN7, Q68G48
      Related
      ENSRNOP00000061541.3, ENSRNOT00000065997.3
      Conserved Domains (1) summary
      cd02894
      Location:18 → 301
      GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      245504586..245510878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281366.1 → XP_063137436.1  geranylgeranyl transferase type-2 subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q08603

    2. XM_063281367.1 → XP_063137437.1  geranylgeranyl transferase type-2 subunit beta isoform X2

    3. XM_063281368.1 → XP_063137438.1  geranylgeranyl transferase type-2 subunit beta isoform X3

      UniProtKB/Swiss-Prot
      Q08603
      UniProtKB/TrEMBL
      A6HWN9

    4. XM_063281369.1 → XP_063137439.1  geranylgeranyl transferase type-2 subunit beta isoform X4

      UniProtKB/TrEMBL
      A6HWP3

    RNA

    1. XR_010063585.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08603.1 GenPept UniProtKB/Swiss-Prot:Q08603

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