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    Notch1 notch receptor 1 [ Rattus rattus (black rat) ]

    Gene ID: 116901266, updated on 18-Mar-2024

    Summary

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    Gene symbol
    Notch1
    Gene description
    notch receptor 1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus rattus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Orthologs
    human mouse all
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    Genomic context

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    See Notch1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    100 current Rrattus_CSIRO_v1 (GCF_011064425.1) 5 NC_046158.1 (10588654..10634419)

    Chromosome 5 - NC_046158.1Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene EGF like domain multiple 7 Neighboring gene U6 spliceosomal RNA Neighboring gene SEC16 homolog A, endoplasmic reticulum export factor Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene peptidase, mitochondrial processing subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_046158.1 Chromosome 5 Reference Rrattus_CSIRO_v1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A homolog of Drosophila Notch expressed during mammalian development. Weinmaster G, et al. Development, 1991 Sep. PMID 1764995
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurogenic locus notch homolog protein 1
    Names
    notch protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Rattus rattus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rrattus_CSIRO_v1 Primary Assembly

    Genomic

    1. NC_046158.1 Reference Rrattus_CSIRO_v1 Primary Assembly

      Range
      10588654..10634419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_032903023.1 → XP_032758914.1  neurogenic locus notch homolog protein 1

      Conserved Domains (11) summary
      smart00004
      Location:1442 → 1479
      NL; Domain found in Notch and Lin-12
      COG0666
      Location:1921 → 2111
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:869 → 905
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:1870 → 1915
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:1532 → 1561
      Notch; LNR domain
      pfam03154
      Location:2124 → 2493
      Atrophin-1; Atrophin-1 family
      pfam06816
      Location:1567 → 1621
      NOD; NOTCH protein
      pfam07684
      Location:1663 → 1719
      NODP; NOTCH protein
      pfam11936
      Location:2455 → 2516
      DUF3454; Domain of unknown function (DUF3454)
      pfam12796
      Location:1922 → 2015
      Ank_2; Ankyrin repeats (3 copies)
      cd21702
      Location:1710 → 1789
      JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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