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    Hrh3 histamine receptor H3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85268, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hrh3provided by RGD
    Official Full Name
    histamine receptor H3provided by RGD
    Primary source
    RGD:620630
    See related
    EnsemblRapid:ENSRNOG00000061153 AllianceGenome:RGD:620630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    This gene encodes a histamine H3 receptor that belongs to the superfamily of G-protein coupled receptors. This protein functions as a presynaptic autoreceptor on histamine neurons in the brain, and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. It is deemed a great target for the development of therapeutics for numerous disorders, including obesity, epilepsy, and such cognitive diseases as attention deficit hyperactivity disorder and Alzheimer's disease. Several alternatively spliced transcript variants encoding different isoforms, with different brain expression patterns and signaling properties, have been described for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in Brain (RPKM 50.6), Thymus (RPKM 18.3) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hrh3 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (187569174..187575263, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167191551..167196642, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (175474310..175479395, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SS18L1 subunit of BAF chromatin remodeling complex Neighboring gene mitochondrial ribosome-associated GTPase 2 Neighboring gene oxysterol binding protein-like 2 Neighboring gene uncharacterized LOC120101831 Neighboring gene ADRM1 26S proteasome ubiquitin receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC105370

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heterocyclic compound binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histamine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables organic cyclic compound binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cAMP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gamma-aminobutyric acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of glutamate secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of serotonin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of arachidonate secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of norepinephrine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to forskolin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to organic cyclic compound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    histamine H3 receptor
    Names
    H3R
    HH3R

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270564.1NP_001257493.1  histamine H3 receptor isoform H3B

      See identical proteins and their annotated locations for NP_001257493.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1, and encodes a shorter isoform (H3B, also known as H3S or H3(413)) containing 7 transmembrane domains, but missing part of the third intracellular loop compared to isoform H3A. This isoform is thought to function as the histamine autoreceptor (PMID:22356432).
      Source sequence(s)
      AB015646, AY009371, BC087707, CB735595
      UniProtKB/TrEMBL
      Q541U0
      Related
      ENSRNOP00000090011.1, ENSRNOT00000116829.2
      Conserved Domains (1) summary
      cd15296
      Location:48391
      7tmA_Histamine_H3R; histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001270565.1NP_001257494.1  histamine H3 receptor isoform H3C

      See identical proteins and their annotated locations for NP_001257494.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is alternatively spliced at the 3' end compared to variant 1, and encodes a shorter isoform (H3C, also known as H3(397)) containing 7 transmembrane domains, but missing part of the third intracellular loop compared to isoform H3A.
      Source sequence(s)
      AB015646, BC087707, CB735595
      UniProtKB/Swiss-Prot
      Q9QYN8
      UniProtKB/TrEMBL
      Q5PPG3
      Conserved Domains (1) summary
      cd15296
      Location:48375
      7tmA_Histamine_H3R; histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001270566.1NP_001257495.1  histamine H3 receptor isoform H3D

      See identical proteins and their annotated locations for NP_001257495.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is alternatively spliced at the 3' end compared to variant 1, which results in a frame-shift, and a longer isoform (H3D) containing 6 transmembrane domains and a distinct C-terminus compared to isoform H3A.
      Source sequence(s)
      AB015646, BC087707, DQ112342
      UniProtKB/TrEMBL
      A0A0G2JU84, Q2VJ18
      Conserved Domains (1) summary
      pfam00001
      Location:51230
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. NM_001270567.1NP_001257496.1  histamine H3 receptor isoform H3E

      See identical proteins and their annotated locations for NP_001257496.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is alternatively spliced at the 3' end compared to variant 1, which results in a frame-shift, and a longer isoform (H3E) containing 6 transmembrane domains and a distinct C-terminus compared to isoform H3A.
      Source sequence(s)
      AB015646, BC087707, DQ112343
      UniProtKB/TrEMBL
      A0A0G2JU84, Q2VJ17
      Related
      ENSRNOP00000071828.1, ENSRNOT00000077308.3
      Conserved Domains (1) summary
      pfam00001
      Location:51353
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    5. NM_001270568.1NP_001257497.1  histamine H3 receptor isoform H3F

      See identical proteins and their annotated locations for NP_001257497.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) is alternatively spliced at the 3' end compared to variant 1, which results in a frame-shift, and a longer isoform (H3F) containing 6 transmembrane domains and a distinct C-terminus compared to isoform H3A.
      Source sequence(s)
      AB015646, BC087707
      UniProtKB/TrEMBL
      A0A0G2JU84
      Conserved Domains (1) summary
      pfam00001
      Location:51337
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    6. NM_001270569.1NP_001257498.1  histamine H3 receptor isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) is alternatively spliced at the 3' end compared to variant 1, and encodes a shorter isoform (7, also known as H3(410)) containing 7 transmembrane domains, but missing part of the third intracellular loop compared to isoform H3A.
      Source sequence(s)
      AB015646, AY009371, BC087707, CB735595
      UniProtKB/TrEMBL
      Q541U0, Q5PPG3
      Conserved Domains (1) summary
      pfam00001
      Location:51377
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    7. NM_001270570.1NP_001257499.1  histamine H3 receptor isoform 8

      See identical proteins and their annotated locations for NP_001257499.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) is alternatively spliced at the 3' end and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. The latter causes a frame-shift, and a shorter isoform (8) containing 6 transmembrane domains and missing part of the third intracellular loop compared to isoform H3A.
      Source sequence(s)
      AB015646, BC087707
      UniProtKB/TrEMBL
      Q5PPG3
      Conserved Domains (1) summary
      pfam00001
      Location:51337
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    8. NM_053506.2NP_445958.1  histamine H3 receptor isoform H3A

      See identical proteins and their annotated locations for NP_445958.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform H3A (also known as H3L or H3(445)), which contains 7 transmembrane domains.
      Source sequence(s)
      AB015646, BC087707, CB735595
      UniProtKB/Swiss-Prot
      Q9QYN6, Q9QYN7, Q9QYN8, Q9QYN9
      UniProtKB/TrEMBL
      A6KMB7
      Related
      ENSRNOP00000069003.2, ENSRNOT00000086761.3
      Conserved Domains (1) summary
      cd15296
      Location:48423
      7tmA_Histamine_H3R; histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. NR_073042.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9, also known as H3T or H3(nf1)) uses an alternate donor splice site at the 5' terminal exon compared to variant 1. It is represented as non-coding because the use of the translational start codon (with a strong Kozak signal), as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB015646, BC087707, CB735595

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      187569174..187575263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284743.1XP_063140813.1  histamine H3 receptor isoform X2

    2. XM_063284742.1XP_063140812.1  histamine H3 receptor isoform X1

    3. XM_063284745.1XP_063140815.1  histamine H3 receptor isoform X1

    4. XM_063284747.1XP_063140817.1  histamine H3 receptor isoform X1

    5. XM_063284746.1XP_063140816.1  histamine H3 receptor isoform X1

    6. XM_008762548.4XP_008760770.1  histamine H3 receptor isoform X1

      Conserved Domains (1) summary
      pfam00001
      Location:186230
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    7. XM_063284744.1XP_063140814.1  histamine H3 receptor isoform X1