Oprk1 opioid receptor, kappa 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oprk1provided by RGD
Official Full Name: opioid receptor, kappa 1provided by RGD
Primary source: RGD:69426
See related: EnsemblRapid:ENSRNOG00000007647 AllianceGenome:RGD:69426
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression: Biased expression in Brain (RPKM 22.9), Thymus (RPKM 5.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (18657866..18675671, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (13860016..13877823, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (13742655..13760460, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kappa opioid receptor mediated operant performance in male and female rats.
Title: Kappa opioid receptor mediated operant performance in male and female rats.
Central delta/kappa opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation.
Title: Central δ/κ opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation.
The role of miRNA-144-3p/Oprk1/KOR in nicotine dependence and nicotine withdrawal in male rats.
Title: The role of miRNA-144-3p/Oprk1/KOR in nicotine dependence and nicotine withdrawal in male rats.
Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH::Cre rats.
Title: Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH::Cre rats.
Dynorphin-kappa-opioid receptor signaling, but not micro-opioid receptor signaling, partly mediates the suppression of luteinizing hormone release during late lactation in rats.
Title: Dynorphin-κ-opioid receptor signaling, but not µ-opioid receptor signaling, partly mediates the suppression of luteinizing hormone release during late lactation in rats.
Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides.
Title: Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides.
Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors.
Title: Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors.
kappa-opioid receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling.
Title: κ-opioid receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling.
Kappa opioid receptors in the central amygdala modulate spinal nociceptive processing through an action on amygdala CRF neurons.
Title: Kappa opioid receptors in the central amygdala modulate spinal nociceptive processing through an action on amygdala CRF neurons.
kappa-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance.
Title: κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94595 (e-PCR)
- UniSTS:119843

GDB:511382 (e-PCR)
- UniSTS:157504

BF403255 (e-PCR)
- UniSTS:246365

D5Wox26 (e-PCR)
- UniSTS:518548

Oprk1 (e-PCR), detects polymorphism
- UniSTS:144086

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled opioid receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled opioid receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables dynorphin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables dynorphin receptor activity	ISO Inferred from Sequence Orthology more info
enables dynorphin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in conditioned place preference	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in maternal behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of luteinizing hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dopamine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of saliva secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of saliva secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to acrylamide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to auditory stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kappa-type opioid receptor

Names: K-OR-1; KOR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318742.1 → NP_001305671.1 kappa-type opioid receptor isoform 1x

Status: REVIEWED

Description

Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.

Source sequence(s)

JAXUCZ010000005

Conserved Domains (2) summary

pfam00001
Location:76 → 330

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:70 → 312

7tm_4; Olfactory receptor
NM_017167.3 → NP_058863.1 kappa-type opioid receptor isoform 1

See identical proteins and their annotated locations for NP_058863.1

Status: REVIEWED

Description

Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P34975

UniProtKB/TrEMBL

A6JFI3

Related

ENSRNOP00000010255.1, ENSRNOT00000010254.5

Conserved Domains (2) summary

pfam00001
Location:76 → 330

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:70 → 312

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

18657866..18675671 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109359.2 → XP_038965287.1 kappa-type opioid receptor isoform X1

Conserved Domains (1) summary

cd15091
Location:111 → 392

7tmA_Kappa_opioid_R; opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors