Fxyd2 FXYD domain-containing ion transport regulator 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fxyd2provided by RGD
Official Full Name: FXYD domain-containing ion transport regulator 2provided by RGD
Primary source: RGD:2173
See related: EnsemblRapid:ENSRNOG00000016469 AllianceGenome:RGD:2173
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ATP1C; Atp1g1; GNAKATP
Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. This gene, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. Related gene family members have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members, with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Two transcript variants have been described for this gene that encode distinct isoforms. [provided by RefSeq, Jan 2010]
Expression: Restricted expression toward (RPKM 3782.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (54609658..54616788)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (45712901..45720032)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (49710334..49717492)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Post-transcriptional control of Na,K-ATPase activity and cell growth by a splice variant of FXYD2 protein with modified mRNA.
Title: Post-transcriptional control of Na,K-ATPase activity and cell growth by a splice variant of FXYD2 protein with modified mRNA.
Differential regulation of renal Na,K-ATPase by splice variants of the gamma subunit
Title: Differential regulation of renal Na,K-ATPase by splice variants of the gamma subunit.
Data describe the interactions of rat FXYD1,-2, and -4 proteins with rat alpha1 subunits of Na(+),K(+)-ATPase.
Title: Structural interactions between FXYD proteins and Na+,K+-ATPase: alpha/beta/FXYD subunit stoichiometry and cross-linking.
splice variants can differentially modulate the major intrinsic properties of the Na,K-ATPase under normal and stress-related conditions
Title: Gamma structural variants differentially regulate Na,K-ATPase properties.
stress inducers (heat shock, exogenous oxidation, and chemical stress) resulted in a selective induction of gammaa isoform and a significant reduction (up to 60%) of Na,K-ATPase activity
Title: Stress-induced expression of the gamma subunit (FXYD2) modulates Na,K-ATPase activity and cell growth.
the unchanged levels of FXYD2 and FXYD4 proteins suggest that they are not primary determinants for urine electrolyte composition during NaCl depletion.
Title: Locations, abundances, and possible functions of FXYD ion transport regulators in rat renal medulla.
the TM domain of FYXD2 effects the shift in apparent Na+ affinity
Title: Modulation of Na,K-ATPase by the gamma subunit: studies with transfected cells and transmembrane mimetic peptides.
study provides the first systematic analysis of structure-function relations of corticosteroid hormone-induced factor and Na,K-ATPase gamma subunit gamma
Title: Structure-function relations of interactions between Na,K-ATPase, the gamma subunit, and corticosteroid hormone-induced factor.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables ion channel regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular hyperosmotic salinity response	IEP Inferred from Expression Pattern more info	PubMed
involved_in inorganic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of P-type sodium:potassium-exchanging transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of P-type sodium:potassium-exchanging transporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of P-type sodium:potassium-exchanging transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of sodium:potassium-exchanging ATPase complex	IDA Inferred from Direct Assay more info	PubMed
part_of sodium:potassium-exchanging ATPase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit gamma

Names: ATPase, Na+/K+ transporting, gamma 1 polypeptide; FXTD domain-containing ion transport regulator 2; Na(+)/K(+) ATPase subunit gamma; gamma subunit of sodium potassium ATPase; sodium pump gamma chain; sodium/potassium-transporting ATPase gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017349.3 → NP_059045.2 sodium/potassium-transporting ATPase subunit gamma isoform b

See identical proteins and their annotated locations for NP_059045.2

Status: VALIDATED

Description

Transcript Variant: This variant (b) contains an alternate exon in the 5' coding region and 5' UTR, compared to variant a. This results in a shorter protein (isoform b) that has a distinct N-terminus, compared to isoform a.

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8L2QTU3, A6J442

Related

ENSRNOP00000061133.3, ENSRNOT00000064611.5

Conserved Domains (1) summary

cd20318
Location:8 → 50

FXYD2; FXYD domain-containing ion transport regulator 2
NM_145717.2 → NP_663769.1 sodium/potassium-transporting ATPase subunit gamma isoform a

See identical proteins and their annotated locations for NP_663769.1

Status: VALIDATED

Description

Transcript Variant: This variant (a) encodes the longer isoform (a).

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q04679, Q9JKN3, Q9WUD3

UniProtKB/TrEMBL

A0A8L2QTU3, A6J444

Related

ENSRNOP00000109670.1, ENSRNOT00000168026.1

Conserved Domains (1) summary

cd20318
Location:10 → 52

FXYD2; FXYD domain-containing ion transport regulator 2