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    Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clpxprovided by RGD
    Official Full Name
    caseinolytic mitochondrial matrix peptidase chaperone subunit Xprovided by RGD
    Primary source
    RGD:1304883
    See related
    EnsemblRapid:ENSRNOG00000030225 AllianceGenome:RGD:1304883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and peptidase activator activity. Predicted to contribute to ATP-dependent peptidase activity. Predicted to be involved in ATP metabolic process and proteolysis involved in protein catabolic process. Predicted to be located in cytosol; mitochondrial nucleoid; and nucleoplasm. Predicted to be part of mitochondrial endopeptidase Clp complex. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in erythropoietic protoporphyria. Orthologous to human CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1351.0), Heart (RPKM 603.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clpx in Genome Data Viewer
    Location:
    8q24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (74700602..74740244)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (65805460..65845643)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (70789137..70843133)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480196 Neighboring gene poly (ADP-ribose) polymerase family, member 16 Neighboring gene cartilage intermediate layer protein Neighboring gene programmed cell death 7 Neighboring gene ubiquitin associated protein 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX. Lowth BR, et al. J Struct Biol, 2012 Aug. PMID 22710082
    2. Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX. Kang SG, et al. J Biol Chem, 2005 Oct 21. PMID 16115876
    3. Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP. Kang SG, et al. J Biol Chem, 2002 Jun 7. PMID 11923310
    4. Human and mouse mitochondrial orthologs of bacterial ClpX. Corydon TJ, et al. Mamm Genome, 2000 Oct. PMID 11003706
    5. Mitochondrial localization and oligomeric structure of HClpP, the human homologue of E. coli ClpP. de Sagarra MR, et al. J Mol Biol, 1999 Oct 1. PMID 10525407

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94617

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ATP-dependent peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ATP-dependent peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis involved in protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of endopeptidase Clp complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of endopeptidase Clp complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial endopeptidase Clp complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial endopeptidase Clp complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
    Names
    ClpX caseinolytic peptidase X homolog
    ClpX caseinolytic protease X homolog
    caseinolytic peptidase X
    caseinolytic protease X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007803.2 → NP_001007804.1  ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001007804.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5U2U0
      UniProtKB/TrEMBL
      A0A8I6A7H5, A6J5E7
      Related
      ENSRNOP00000088647.2, ENSRNOT00000097161.2
      Conserved Domains (4) summary
      smart01086
      Location:509 → 603
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
      TIGR00382
      Location:102 → 600
      clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)
      pfam07724
      Location:286 → 502
      AAA_2; AAA domain (Cdc48 subfamily)
      cl02609
      Location:104 → 132
      Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      74700602..74740244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243250.3 → XP_006243312.1  ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7H5
      Related
      ENSRNOP00000088175.1, ENSRNOT00000103006.2
      Conserved Domains (4) summary
      smart01086
      Location:495 → 589
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
      TIGR00382
      Location:102 → 586
      clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)
      pfam07724
      Location:272 → 488
      AAA_2; AAA domain (Cdc48 subfamily)
      cl02609
      Location:104 → 132
      Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

    RNA

    1. XR_005487776.2 RNA Sequence

    2. XR_010053949.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2U0.1 GenPept UniProtKB/Swiss-Prot:Q5U2U0

    Gene LinkOut

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