Acta1 actin, alpha 1, skeletal muscle [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acta1provided by RGD
Official Full Name: actin, alpha 1, skeletal muscleprovided by RGD
Primary source: RGD:2025
See related: EnsemblRapid:ENSRNOG00000017786 AllianceGenome:RGD:2025
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP binding activity; hydrolase activity; and protein kinase binding activity. Involved in several processes, including cellular response to potassium ion; response to steroid hormone; and skeletal muscle fiber adaptation. Predicted to be located in several cellular components, including filopodium; lamellipodium; and sarcomere. Predicted to be part of protein-containing complex. Predicted to be active in actin filament; stress fiber; and striated muscle thin filament. Human ortholog(s) of this gene implicated in congenital myopathy 2B; congenital myopathy 2C; and nemaline myopathy 3. Orthologous to human ACTA1 (actin alpha 1, skeletal muscle). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 144696.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (68781168..68784194, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (51883709..51886735, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (56674072..56677084, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of the pattern of of evolutionarily conserved basic and acidic residues that constitutes the binding interface of actin-tropomyosin
Title: A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin.
The effects of reactive oxygen species on tryptophan residues in alpha skeletal actin and troponin I, was investigated.
Title: Quantitative evaluation of tryptophan oxidation in actin and troponin I from skeletal muscles using a rat model of acute oxidative stress.
SHP2 negatively regulates alpha-SKA expression via RhoA inactivation and suggest that SHP2 implicates ERK5 in cardiomyocyte elongation downstream of gp130.
Title: SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene.
actin cytoskeletal mechanics are an essential feature of the glucose transport process in intact skeletal muscle
Title: Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156124P2 (e-PCR)
- UniSTS:271360

PMC201106P1 (e-PCR)
- UniSTS:271883

PMC156330P1 (e-PCR)
- UniSTS:271392

PMC151529P1 (e-PCR)
- UniSTS:271148

PMC108612P1 (e-PCR)
- UniSTS:270141

PMC133768P1 (e-PCR)
- UniSTS:270660

PMC109669P1 (e-PCR)
- UniSTS:270176

AA959943 (e-PCR)
- UniSTS:159840

PMC110143P1 (e-PCR)
- UniSTS:270184

PMC133998P8 (e-PCR)
- UniSTS:270713

PMC209527P1 (e-PCR)
- UniSTS:271999

LOC345651 (e-PCR)
- UniSTS:265879

PMC87052P1 (e-PCR)
- UniSTS:273574

Acta1 (e-PCR), detects polymorphism
- UniSTS:141013

Acta1 (e-PCR), detects polymorphism
- UniSTS:141014

Acta1 (e-PCR), detects polymorphism
- UniSTS:478947

AI704778 (e-PCR)
- UniSTS:243440

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to potassium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in glomerular mesangial cell development	IEA Inferred from Electronic Annotation more info
involved_in mesenchyme migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle fiber adaptation	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber development	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle thin filament assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle thin filament assembly	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle thin filament assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info
located_in smooth muscle contractile fiber	IEA Inferred from Electronic Annotation more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info
is_active_in striated muscle thin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle thin filament	ISO Inferred from Sequence Orthology more info
located_in striated muscle thin filament	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin, alpha skeletal muscle

Names: actin alpha 1; alpha-actin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.