Lefty2 Left-right determination factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lefty2provided by RGD
Official Full Name: Left-right determination factor 2provided by RGD
Primary source: RGD:1359679
See related: EnsemblRapid:ENSRNOG00000060325 AllianceGenome:RGD:1359679
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ebaf2
Summary: Predicted to enable cytokine activity. Predicted to be involved in anterior/posterior axis specification. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human LEFTY1 (left-right determination factor 1) and LEFTY2 (left-right determination factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 25.7) and Adrenal (RPKM 8.5) See more
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Genomic context

Location:: 13q26

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (95147139..95151657)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (92610185..92620918)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (99173484..99178037)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of EBAF/Nodal/p27 signaling pathway in development of placenta in normal and diabetic rats.
Title: Role of EBAF/Nodal/p27 signaling pathway in development of placenta in normal and diabetic rats.
LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-beta1/Smad3 pathway.
Title: LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.
These observations have shed new light on the relevance of the NODAL/LEFTY2 pathway in the oviduct during early embryo development and the role of the embryo in modulating this pathway.
Title: Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in vivo.
LEFTY2 is expressed at a high level just before the embryos pass to the uterus; its biological effect might be relevant and significant for the preimplantation stage of embryo development in the oviduct.
Title: LEFTY2 expression and localization in rat oviduct during early pregnancy.
The highest expression of lefty2 was at the 4(th) day after mating (five folds respect to day one), just when the embryos have completed their transit through the oviduct.
Title: Rat Lefty2/EBAF gene: isolation and expression analysis in the oviduct during the early pregnancy stage.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: left-right determination factor 2

Names: endometrial bleeding associated factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.