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    Cd74 CD74 molecule [ Rattus rattus (black rat) ]

    Gene ID: 116884619, updated on 18-Mar-2024

    Summary

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    Gene symbol
    Cd74
    Gene description
    CD74 molecule
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus rattus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Orthologs
    human mouse all
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    Genomic context

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    See Cd74 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    100 current Rrattus_CSIRO_v1 (GCF_011064425.1) 15 NC_046168.1 (71132199..71141584, complement)

    Chromosome 15 - NC_046168.1Genomic Context describing neighboring genes Neighboring gene arylsulfatase family member I Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene ribosomal protein S14 Neighboring gene N-deacetylase and N-sulfotransferase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_046168.1 Chromosome 15 Reference Rrattus_CSIRO_v1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of a rat MHC class II-associated invariant chain cDNA clone containing a 64 amino acid thyroglobulin-like domain. McKnight AJ, et al. Nucleic Acids Res, 1989 May 25. PMID 2499873, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables macrophage migration inhibitory factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of type 2 immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein trimerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HLA class II histocompatibility antigen gamma chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Rattus rattus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rrattus_CSIRO_v1 Primary Assembly

    Genomic

    1. NC_046168.1 Reference Rrattus_CSIRO_v1 Primary Assembly

      Range
      71132199..71141584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_032885760.1 → XP_032741651.1  HLA class II histocompatibility antigen gamma chain

      Conserved Domains (3) summary
      cd00191
      Location:196 → 255
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam08831
      Location:120 → 185
      MHCassoc_trimer; Class II MHC-associated invariant chain trimerisation domain
      pfam09307
      Location:1 → 113
      MHC2-interact; CLIP, MHC2 interacting
    Nucleotide Protein
    Heading Accession and Version

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