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    Tcea3 transcription elongation factor A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298559, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcea3provided by RGD
    Official Full Name
    transcription elongation factor A3provided by RGD
    Primary source
    RGD:1311369
    See related
    EnsemblRapid:ENSRNOG00000011794 AllianceGenome:RGD:1311369
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human TCEA3 (transcription elongation factor A3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 516.6), Kidney (RPKM 142.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tcea3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153760401..153792934)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148476941..148509452)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154598765..154634687)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479041 Neighboring gene E2F transcription factor 2 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC134487016 Neighboring gene immunoglobulin heavy chain 6 like 1 Neighboring gene zinc finger protein 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Control of transcriptional elongation. Kwak H, et al. Annu Rev Genet, 2013. PMID 24050178, Free PMC Article
    2. Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Nishiyama A, et al. Cell Stem Cell, 2009 Oct 2. PMID 19796622, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108819

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A protein 3
    Names
    transcription elongation factor A (SII), 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015008.1 → NP_001015008.1  transcription elongation factor A protein 3

      See identical proteins and their annotated locations for NP_001015008.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091180
      UniProtKB/TrEMBL
      F7EY03, Q5BK74
      Conserved Domains (4) summary
      cd00183
      Location:4 → 80
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cd13749
      Location:301 → 347
      Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
      TIGR01385
      Location:5 → 348
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:185 → 292
      TFIIS_M; Transcription factor S-II (TFIIS), central domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153760401..153792934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287455.1 → XP_063143525.1  transcription elongation factor A protein 3 isoform X1

      UniProtKB/TrEMBL
      F7EY03, Q5BK74
      Related
      ENSRNOP00000015776.6, ENSRNOT00000015776.8
    Nucleotide Protein Strain
    Heading Accession and Version

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