Ptprn protein tyrosine phosphatase, receptor type, N [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprnprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Nprovided by RGD
Primary source: RGD:620777
See related: EnsemblRapid:ENSRNOG00000019587 AllianceGenome:RGD:620777
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ia-2; BEM-3; PTPLP; ICA105; ICA512; R-PTP-N
Summary: Enables GTPase binding activity. Involved in several processes, including positive regulation of type B pancreatic cell proliferation; response to cAMP; and response to estrogen. Located in several cellular components, including axon terminus; cytoplasmic vesicle; and neuronal cell body. Is active in neuronal dense core vesicle membrane. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 408.1), Kidney (RPKM 140.4) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (84189676..84205364, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (76741010..76756704, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (82446626..82462314, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings point to ICA512 RESP18HD being a condensing factor for protein sorting and granulogenesis early in the secretory pathway and for prevention of amyloidogenesis.
Title: ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor.
The ME ICA512 beta2-strand fosters proICA512 dimerization until NTF prevents N506 glycosylation.
Title: Stability of proICA512/IA-2 and its targeting to insulin secretory granules require β4-sheet-mediated dimerization of its ectodomain in the endoplasmic reticulum.
In the stomach, IA-2 and IA-2beta were expressed in gastrointestinal endocrine cells that secrete serotonin, somatostatin, and cholecystokinin/gastrin-1.
Title: Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells.
ICA512 is a regulator of cyclins D and beta-cell proliferation through STAT3 and STAT5
Title: ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets: relationship to development of insulin secretory responses in early life.
Title: Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets: relationship to development of insulin secretory responses in early life.
Data show that PTP-NP rapidly associates with Dynamin-1 in a depolarization-dependent manner and regulates Dynamin-1 GTPase activity upon KCl depolarization of rat primary hippocampal neurons.
Title: Receptor-type PTP-NP inhibition of Dynamin-1 GTPase activity is associated with neuronal depolarization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131806 (e-PCR)
- UniSTS:215089

D9Mco68 (e-PCR)
- UniSTS:518456

MARC_8095-8096:996688286:1 (e-PCR)
- UniSTS:269893

PTPRN_1350 (e-PCR)
- UniSTS:277628

PTPRN_v432 (e-PCR)
- UniSTS:277628

D9Mco44 (e-PCR)
- UniSTS:518544

X74438 (e-PCR)
- UniSTS:163252

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
NOT enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
NOT enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables spectrin binding	IEA Inferred from Electronic Annotation more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dense core granule maturation	IEA Inferred from Electronic Annotation more info
involved_in dense core granule maturation	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion involved in cellular response to glucose stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in luteinization	ISO Inferred from Sequence Orthology more info
involved_in luteinization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type B pancreatic cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type B pancreatic cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
involved_in response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
NOT located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase-like N

Names: 105 kDa islet cell antigen; brain-enriched membrane-associated protein tyrosine phosphatase

NP_446333.2

EC 3.1.3.48

XP_006245196.1

EC 3.1.3.48

XP_017451718.1

EC 3.1.3.48

XP_017451719.1

EC 3.1.3.48

XP_063122605.1

EC 3.1.3.48

XP_063122606.1

EC 3.1.3.48

XP_063122607.1

EC 3.1.3.48

XP_063122608.1

EC 3.1.3.48

XP_063122609.1

EC 3.1.3.48

XP_063122610.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053881.2 → NP_446333.2 receptor-type tyrosine-protein phosphatase-like N precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q62883, Q63259, Q63795, Q64643

UniProtKB/TrEMBL

A0A8I6A9W6, A6JW12

Related

ENSRNOP00000026654.6, ENSRNOT00000026654.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

84189676..84205364 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596230.3 → XP_017451719.1 receptor-type tyrosine-protein phosphatase-like N isoform X3

UniProtKB/TrEMBL

A0A8I5ZW92
XM_017596229.2 → XP_017451718.1 receptor-type tyrosine-protein phosphatase-like N isoform X2

UniProtKB/TrEMBL

A0A8I5ZW92
XM_063266535.1 → XP_063122605.1 receptor-type tyrosine-protein phosphatase-like N isoform X1

UniProtKB/TrEMBL

A0A8I5ZW92
XM_063266536.1 → XP_063122606.1 receptor-type tyrosine-protein phosphatase-like N isoform X4

UniProtKB/TrEMBL

A0A8I6A9W6
XM_063266538.1 → XP_063122608.1 receptor-type tyrosine-protein phosphatase-like N isoform X6

UniProtKB/TrEMBL

A0A8I6A9W6
XM_063266537.1 → XP_063122607.1 receptor-type tyrosine-protein phosphatase-like N isoform X5

UniProtKB/TrEMBL

A0A8I6A9W6
XM_006245134.5 → XP_006245196.1 receptor-type tyrosine-protein phosphatase-like N isoform X7

UniProtKB/TrEMBL

A0A8I6A9W6, A0A8L2QEF0

Conserved Domains (5) summary

smart00194
Location:714 → 973

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:741 → 973

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam06365
Location:526 → 650

CD34_antigen; CD34/Podocalyxin family

pfam11548
Location:477 → 562

Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2

pfam14948
Location:66 → 144

RESP18; RESP18 domain
XM_063266539.1 → XP_063122609.1 receptor-type tyrosine-protein phosphatase-like N isoform X8

UniProtKB/TrEMBL

A0A8I5ZW92
XM_063266540.1 → XP_063122610.1 receptor-type tyrosine-protein phosphatase-like N isoform X9

UniProtKB/TrEMBL

A0A8I5ZW92

Related

ENSRNOP00000081951.1, ENSRNOT00000094318.2