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    Cmah cytidine monophospho-N-acetylneuraminic acid hydroxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361245, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cmahprovided by RGD
    Official Full Name
    cytidine monophospho-N-acetylneuraminic acid hydroxylaseprovided by RGD
    Primary source
    RGD:1311930
    See related
    EnsemblRapid:ENSRNOG00000003094 AllianceGenome:RGD:1311930
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cmahp
    Summary
    Predicted to enable CMP-N-acetylneuraminate monooxygenase activity. Predicted to be involved in CMP-N-acetylneuraminate metabolic process and regulation of Wnt signaling pathway. Predicted to be located in cytoskeleton; membrane; and nucleus. Predicted to be active in cytoplasm. Orthologous to human CMAHP (cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 634.2), Spleen (RPKM 281.7) and 3 other tissues See more
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    Genomic context

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    See Cmah in Genome Data Viewer
    Location:
    17p11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (40985129..41070317, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (40557161..40642350, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (42567472..42640221, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene armadillo-like helical domain containing 2 Neighboring gene RHO family interacting cell polarization regulator 2 Neighboring gene uncharacterized LOC102552189 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene adaptor related protein complex 1 subunit beta 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sexual selection by female immunity against paternal antigens can fix loss of function alleles. Ghaderi D, et al. Proc Natl Acad Sci U S A, 2011 Oct 25. PMID 21987817, Free PMC Article
    2. Human CMP-N-acetylneuraminic acid hydroxylase is a novel stem cell marker linked to stem cell-specific mechanisms. Nystedt J, et al. Stem Cells, 2010 Feb. PMID 19890979
    3. Molecular cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase. Regulation of species- and tissue-specific expression of N-glycolylneuraminic acid. Kawano T, et al. J Biol Chem, 1995 Jul 7. PMID 7608218
    4. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. Bergfeld AK, et al. J Biol Chem, 2012 Aug 17. PMID 22692205, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CMP-N-acetylneuraminate monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CMP-N-acetylneuraminate monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP-N-acetylneuraminate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within CMP-N-acetylneuraminate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-acetylneuraminate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytidine monophospho-N-acetylneuraminic acid hydroxylase; cytidine monophospho-N-acetylneuraminic acid hydroxylase,
    Names
    CMP-N-acetylneuraminate monooxygenase
    cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-N-acetylneuraminate monooxygenase)
    cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
    NP_001019444.1
    XP_038951815.1
    XP_038951816.1
    XP_038951817.1
    XP_038951818.1
    XP_038951819.1
    XP_063132677.1
    XP_063132678.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024273.1 → NP_001019444.1  cytidine monophospho-N-acetylneuraminic acid hydroxylase

      See identical proteins and their annotated locations for NP_001019444.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095843
      UniProtKB/TrEMBL
      F1LNX8
      Conserved Domains (2) summary
      COG2220
      Location:135 → 221
      UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
      cd03473
      Location:6 → 111
      Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      40985129..41070317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095890.2 → XP_038951818.1  cytidine monophospho-N-acetylneuraminic acid hydroxylase, isoform X1

      UniProtKB/TrEMBL
      F1LNX8
      Conserved Domains (2) summary
      COG2220
      Location:135 → 221
      UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
      cd03473
      Location:6 → 111
      Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...

    2. XM_063276608.1 → XP_063132678.1  cytidine monophospho-N-acetylneuraminic acid hydroxylase, isoform X1

      UniProtKB/TrEMBL
      F1LNX8

    3. XM_039095889.2 → XP_038951817.1  cytidine monophospho-N-acetylneuraminic acid hydroxylase, isoform X1

      UniProtKB/TrEMBL
      F1LNX8
      Conserved Domains (2) summary
      COG2220
      Location:135 → 221
      UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
      cd03473
      Location:6 → 111
      Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...

    4. XM_039095887.2 → XP_038951815.1  cytidine monophospho-N-acetylneuraminic acid hydroxylase, isoform X1

      UniProtKB/TrEMBL
      F1LNX8
      Related
      ENSRNOP00000018699.8, ENSRNOT00000018699.9
      Conserved Domains (2) summary
      COG2220
      Location:135 → 221
      UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
      cd03473
      Location:6 → 111
      Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...

    5. XM_063276607.1 → XP_063132677.1  cytidine monophospho-N-acetylneuraminic acid hydroxylase, isoform X1

      UniProtKB/TrEMBL
      F1LNX8

    6. XM_039095888.2 → XP_038951816.1  cytidine monophospho-N-acetylneuraminic acid hydroxylase, isoform X1

      UniProtKB/TrEMBL
      F1LNX8
      Conserved Domains (2) summary
      COG2220
      Location:135 → 221
      UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
      cd03473
      Location:6 → 111
      Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...

    7. XM_039095891.2 → XP_038951819.1  cytidine monophospho-N-acetylneuraminic acid hydroxylase, isoform X2

      UniProtKB/TrEMBL
      F1LNX8
      Related
      ENSRNOP00000083998.2, ENSRNOT00000106094.2
      Conserved Domains (3) summary
      COG2220
      Location:135 → 221
      UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
      cd03473
      Location:6 → 111
      Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...
      cl23716
      Location:158 → 307
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    RNA

    1. XR_010058898.1 RNA Sequence

    2. XR_010058899.1 RNA Sequence

    3. XR_005495302.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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