Cyct cytochrome c, testis [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyctprovided by RGD
Official Full Name: cytochrome c, testisprovided by RGD
Primary source: RGD:2452
See related: EnsemblRapid:ENSRNOG00000077437 AllianceGenome:RGD:2452
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CYCTA
Summary: Predicted to enable electron transfer activity and heme binding activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to act upstream of or within hydrogen peroxide metabolic process and positive regulation of intrinsic apoptotic signaling pathway. Predicted to be active in mitochondrial intermembrane space. Orthologous to human CYCTP (cytochrome c, testis, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 345.1) See more
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Genomic context

Location:: 3q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (81697333..81704401, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (61290090..61297158, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (63204779..63211847, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that heat stress of testes triggers the release of cytochrome c from mitochondria in spermatogenic cells, leading to the activation of an apoptotic pathway.
Title: Suppression of cytochrome c release and apoptosis in testes with heat stress by minocycline.

Submit: New GeneRIF Correction

General gene information

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Markers

ANP32C__4314 (e-PCR)
- UniSTS:463541

AU047925 (e-PCR)
- UniSTS:110041

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hydrogen peroxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome c, testis-specific

Names: Cytochrome C testis specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012840.3 → NP_036972.1 cytochrome c, testis-specific

See identical proteins and their annotated locations for NP_036972.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003, M20623

UniProtKB/Swiss-Prot

P10715

UniProtKB/TrEMBL

A6HMH2

Related

ENSRNOP00000008371.1, ENSRNOT00000008371.5

Conserved Domains (2) summary

COG2010
Location:2 → 101

CccA; Cytochrome c, mono- and diheme variants [Energy production and conversion]

COG3474
Location:1 → 105

Cyc7; Cytochrome c2 [Energy production and conversion]