Scgb1a1 secretoglobin family 1A member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scgb1a1provided by RGD
Official Full Name: secretoglobin family 1A member 1provided by RGD
Primary source: RGD:3934
See related: EnsemblRapid:ENSRNOG00000020196 AllianceGenome:RGD:3934
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ugb; CC10; CC16; CCSP; PCBB
Summary: Enables polychlorinated biphenyl binding activity. Involved in several processes, including response to lipopolysaccharide; response to ozone; and response to silicon dioxide. Located in extracellular space; nuclear envelope; and secretory granule. Biomarker of acute kidney failure; asthma; otitis media; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; and glomerulonephritis. Orthologous to human SCGB1A1 (secretoglobin family 1A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 6387.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (215406138..215409686, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (205977060..205980610, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (225279698..225283246, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silica exposure causes dynamic changes of SP-D and CC16 protein expression in lung tissue and bronchoalveolar lavage fluid.
Title: [Dynamic changes of surfactant protein-D and Clara cell protein expressions in lung tissue and bronchoalveolar lavage fluid of silica-treated rats].
The expression level of CC16 in lung tissues and BALF decreased in rat lung tissues exposed to mixed air pollutants.
Title: [Effects of air mixed certain pollutants on the expression of CC16 and certain cytokine in pulmonary tissue of rats].
Results show that secretory markers such as CFTR, CC10, and CC26 are present in taste cells of rat circumvallate papillae, and their immunoreactivity is expressed, to a different extent, in subsets of taste cells that express alpha-gustducin.
Title: Immunohistochemical localization of cystic fibrosis transmembrane regulator and clara cell secretory protein in taste receptor cells of rat circumvallate papillae.
IL-13 induces CCSP expression via an EGFR- and leukocyte-dependent pathway.
Title: IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway.

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General gene information

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Markers

Scgb1a1 (e-PCR), detects polymorphism
- UniSTS:499112

D1Bda50 (e-PCR)
- UniSTS:239803

RH134311 (e-PCR)
- UniSTS:217593

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phospholipase A2 inhibitor activity	IEA Inferred from Electronic Annotation more info
enables polychlorinated biphenyl binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fibroblast growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ozone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to silicon dioxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: uteroglobin

Names: CCPBP; PCB-binding protein; Uteroglobin (club cell secretory protein); club cell 10 kDa secretory protein; club cell phospholipid-binding protein; club cell protein 16; club cells 10 kDa secretory protein; club secretory protein-16; secretoglobin, family 1A, member 1 (uteroglobin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.