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    Henmt1 HEN methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100363095, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Henmt1provided by RGD
    Official Full Name
    HEN methyltransferase 1provided by RGD
    Primary source
    RGD:1306230
    See related
    EnsemblRapid:ENSRNOG00000042814 AllianceGenome:RGD:1306230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306230
    Summary
    Predicted to enable small RNA 2'-O-methyltransferase activity. Predicted to be involved in RNA methylation; piRNA processing; and siRNA processing. Predicted to be located in P granule. Predicted to be active in cytoplasm and nucleus. Orthologous to human HENMT1 (HEN methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 37.0), Brain (RPKM 9.8) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Henmt1 in Genome Data Viewer
    Location:
    2q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (199258107..199291739)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (196585732..196603700)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (211740571..211753718)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 7 Neighboring gene microRNA 6314 Neighboring gene pre-mRNA processing factor 38B Neighboring gene EEIG family member 2 Neighboring gene 60S ribosomal protein L21 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. 2'-O-methyl modification in mouse piRNAs and its methylase. Kirino Y, et al. Nucleic Acids Symp Ser (Oxf), 2007. PMID 18029764
    2. The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. Kirino Y, et al. RNA, 2007 Sep. PMID 17652135, Free PMC Article
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC125117

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small RNA 2'-O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small RNA 2'-O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in piRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small RNA 2'-O-methyltransferase
    Names
    HEN1 methyltransferase homolog 1
    NP_001032744.2
    XP_038957471.1
    XP_038957472.1
    XP_038957473.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037655.1 → NP_001032744.2  small RNA 2'-O-methyltransferase

      See identical proteins and their annotated locations for NP_001032744.2

      Status: VALIDATED

      Source sequence(s)
      BC107926
      UniProtKB/Swiss-Prot
      Q32PY6
      UniProtKB/TrEMBL
      A6HV35, F1LQ15
      Related
      ENSRNOP00000095551.1, ENSRNOT00000115077.2
      Conserved Domains (1) summary
      pfam13649
      Location:57 → 151
      Methyltransf_25; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      199258107..199291739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101545.2 → XP_038957473.1  small RNA 2'-O-methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q32PY6
      UniProtKB/TrEMBL
      A6HV35, F1LQ15
      Conserved Domains (1) summary
      pfam13649
      Location:57 → 151
      Methyltransf_25; Methyltransferase domain

    2. XM_039101543.2 → XP_038957471.1  small RNA 2'-O-methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q32PY6
      UniProtKB/TrEMBL
      A6HV35, F1LQ15
      Related
      ENSRNOP00000060946.4, ENSRNOT00000066924.5
      Conserved Domains (1) summary
      pfam13649
      Location:57 → 151
      Methyltransf_25; Methyltransferase domain

    3. XM_039101544.2 → XP_038957472.1  small RNA 2'-O-methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q32PY6
      UniProtKB/TrEMBL
      A6HV35, F1LQ15
      Conserved Domains (1) summary
      pfam13649
      Location:57 → 151
      Methyltransf_25; Methyltransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32PY6.1 GenPept UniProtKB/Swiss-Prot:Q32PY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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