Cenpi centromere protein I [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cenpiprovided by RGD
Official Full Name: centromere protein Iprovided by RGD
Primary source: RGD:2631
See related: EnsemblRapid:ENSRNOG00000033335 AllianceGenome:RGD:2631
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LRPR1; RNALRP; Fshprh1
Summary: Involved in follicle-stimulating hormone signaling pathway. Predicted to be located in kinetochore and nuclear body. Predicted to be part of inner kinetochore. Orthologous to human CENPI (centromere protein I). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 45.1), Thymus (RPKM 39.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (101809192..101860935)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (97515919..97567671)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (105147045..105198798)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in CENP-A containing chromatin assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in centromere complex assembly	IEA Inferred from Electronic Annotation more info
involved_in follicle-stimulating hormone signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of inner kinetochore	IBA Inferred from Biological aspect of Ancestor more info
part_of inner kinetochore	IEA Inferred from Electronic Annotation more info
part_of inner kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: centromere protein I

Names: CENP-I; FSH primary response 1; FSH primary response protein 1; Follicle stimulating hormone primary response gene 1 (Leucine - rich primary resonse gene 1); follicle-stimulating hormone primary response protein; leucine-rich primary response protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431555.1 → NP_001418484.1 centromere protein I

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2K7E6, A6IVE9, F1LP20
NM_001431556.1 → NP_001418485.1 centromere protein I

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2K7E6, A6IVE9, F1LP20
NM_001431557.1 → NP_001418486.1 centromere protein I

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2K7E6, A6IVE9, F1LP20
NM_012955.1 → NP_037087.1 centromere protein I

See identical proteins and their annotated locations for NP_037087.1

Status: PROVISIONAL

Source sequence(s)

X90355

UniProtKB/Swiss-Prot

Q63517

UniProtKB/TrEMBL

A0A0G2K7E6

Related

ENSRNOP00000041317.4, ENSRNOT00000046288.6

Conserved Domains (1) summary

pfam07778
Location:12 → 515

CENP-I; Mis6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

101809192..101860935

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257217.5 → XP_006257279.1 centromere protein I isoform X1

Conserved Domains (1) summary

pfam07778
Location:12 → 515

CENP-I; Mis6
XM_006257215.5 → XP_006257277.1 centromere protein I isoform X1

Conserved Domains (1) summary

pfam07778
Location:12 → 515

CENP-I; Mis6
XM_039099502.2 → XP_038955430.1 centromere protein I isoform X2

UniProtKB/TrEMBL

A0A0G2K7E6

Conserved Domains (1) summary

pfam07778
Location:12 → 515

CENP-I; Mis6
XM_006257216.5 → XP_006257278.1 centromere protein I isoform X1

Conserved Domains (1) summary

pfam07778
Location:12 → 515

CENP-I; Mis6