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    Klhl29 kelch-like family member 29 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl29provided by RGD
    Official Full Name
    kelch-like family member 29provided by RGD
    Primary source
    RGD:1311076
    See related
    EnsemblRapid:ENSRNOG00000005371 AllianceGenome:RGD:1311076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kbtbd9
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL29 (kelch like family member 29). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 22.6), Brain (RPKM 20.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl29 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (33805922..34110055, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (28086489..28390647, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (29178858..29483460, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene UBX domain protein 2A Neighboring gene ATPase family, AAA domain containing 2B Neighboring gene uncharacterized LOC134479334 Neighboring gene uncharacterized LOC120103500 Neighboring gene uncharacterized LOC134479335 Neighboring gene uncharacterized LOC103692581 Neighboring gene uncharacterized LOC120103501 Neighboring gene uncharacterized LOC120103502

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189300

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 29
    Names
    kelch repeat and BTB (POZ) domain containing 9
    kelch-like 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106713.3 → NP_001100183.1  kelch-like protein 29

      See identical proteins and their annotated locations for NP_001100183.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AE73, A6HAK4, D4AEF4
      Related
      ENSRNOP00000007160.5, ENSRNOT00000007160.10
      Conserved Domains (5) summary
      PHA03098
      Location:333 → 860
      PHA03098; kelch-like protein; Provisional
      PHA03247
      Location:22 → 290
      PHA03247; large tegument protein UL36; Provisional
      sd00038
      Location:673 → 716
      Kelch; KELCH repeat [structural motif]
      cd18468
      Location:432 → 533
      BACK_KLHL29_KBTBD9; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29)
      cl38908
      Location:312 → 438
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      33805922..34110055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594072.3 → XP_017449561.1  kelch-like protein 29 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AE73, A6HAK4, D4AEF4
      Conserved Domains (5) summary
      PHA03098
      Location:333 → 860
      PHA03098; kelch-like protein; Provisional
      PHA03247
      Location:22 → 290
      PHA03247; large tegument protein UL36; Provisional
      sd00038
      Location:673 → 716
      Kelch; KELCH repeat [structural motif]
      cd18468
      Location:432 → 533
      BACK_KLHL29_KBTBD9; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29)
      cl38908
      Location:312 → 438
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_006239857.5 → XP_006239919.1  kelch-like protein 29 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AE73
      Conserved Domains (6) summary
      smart00612
      Location:875 → 923
      Kelch; Kelch domain
      PHA03098
      Location:386 → 913
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:726 → 769
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:372 → 480
      BTB; BTB/POZ domain
      pfam01344
      Location:725 → 770
      Kelch_1; Kelch motif
      pfam07707
      Location:489 → 590
      BACK; BTB And C-terminal Kelch

    3. XM_039111920.2 → XP_038967848.1  kelch-like protein 29 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AE73, A6HAK4, D4AEF4
      Conserved Domains (5) summary
      PHA03098
      Location:333 → 860
      PHA03098; kelch-like protein; Provisional
      PHA03247
      Location:22 → 290
      PHA03247; large tegument protein UL36; Provisional
      sd00038
      Location:673 → 716
      Kelch; KELCH repeat [structural motif]
      cd18468
      Location:432 → 533
      BACK_KLHL29_KBTBD9; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29)
      cl38908
      Location:312 → 438
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    4. XM_039111919.2 → XP_038967847.1  kelch-like protein 29 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AE73
      Conserved Domains (5) summary
      PHA03098
      Location:409 → 936
      PHA03098; kelch-like protein; Provisional
      PHA03247
      Location:98 → 366
      PHA03247; large tegument protein UL36; Provisional
      sd00038
      Location:749 → 792
      Kelch; KELCH repeat [structural motif]
      cd18468
      Location:508 → 609
      BACK_KLHL29_KBTBD9; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29)
      cl38908
      Location:388 → 514
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    5. XM_008764550.4 → XP_008762772.1  kelch-like protein 29 isoform X4

      See identical proteins and their annotated locations for XP_008762772.1

      UniProtKB/TrEMBL
      A0A8I6AE73, A6HAK4, D4AEF4
      Conserved Domains (5) summary
      PHA03098
      Location:333 → 860
      PHA03098; kelch-like protein; Provisional
      PHA03247
      Location:22 → 290
      PHA03247; large tegument protein UL36; Provisional
      sd00038
      Location:673 → 716
      Kelch; KELCH repeat [structural motif]
      cd18468
      Location:432 → 533
      BACK_KLHL29_KBTBD9; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29)
      cl38908
      Location:312 → 438
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    6. XM_017594070.3 → XP_017449559.1  kelch-like protein 29 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AE73
      Related
      ENSRNOP00000105594.1, ENSRNOT00000161516.1
    Nucleotide Protein Strain
    Heading Accession and Version

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