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    Zfp280d zinc finger protein 280D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315798, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp280dprovided by RGD
    Official Full Name
    zinc finger protein 280Dprovided by RGD
    Primary source
    RGD:1560796
    See related
    EnsemblRapid:ENSRNOG00000055631 AllianceGenome:RGD:1560796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Suhw4; RGD1560796
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human ZNF280D (zinc finger protein 280D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 475.5), Brain (RPKM 145.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp280d in Genome Data Viewer
    Location:
    8q24
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (81872108..81961194)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (72992655..73080482)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (78858561..78949447)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479978 Neighboring gene uncharacterized LOC108351742 Neighboring gene uncharacterized LOC102546620 Neighboring gene ribosomal protein L35, pseudogene 6 Neighboring gene meiosis-specific nuclear structural 1 Neighboring gene testis expressed 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 280D
    Names
    suppressor of hairy wing homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108165.2 → NP_001101635.2  zinc finger protein 280D

      See identical proteins and their annotated locations for NP_001101635.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2JU78, A6KEP7, F1M0V0
      Conserved Domains (3) summary
      sd00017
      Location:360 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:323 → 357
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:45 → 229
      DUF4195; Domain of unknown function (DUF4195)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      81872108..81961194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595664.3 → XP_017451153.1  zinc finger protein 280D isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU78, A6KEP7, F1M0V0
      Related
      ENSRNOP00000068997.1, ENSRNOT00000090047.3
      Conserved Domains (3) summary
      sd00017
      Location:360 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:323 → 357
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:45 → 229
      DUF4195; Domain of unknown function (DUF4195)

    2. XM_063265541.1 → XP_063121611.1  zinc finger protein 280D isoform X3

      UniProtKB/TrEMBL
      A0A8I6ACS8, A6KEQ0

    3. XM_039081514.2 → XP_038937442.1  zinc finger protein 280D isoform X8

      UniProtKB/TrEMBL
      A0A8I6ACS8
      Conserved Domains (2) summary
      sd00017
      Location:360 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:45 → 228
      DUF4195; Domain of unknown function (DUF4195)

    4. XM_063265544.1 → XP_063121614.1  zinc finger protein 280D isoform X9

      UniProtKB/TrEMBL
      A0A8I6ACS8

    5. XM_008766290.4 → XP_008764512.1  zinc finger protein 280D isoform X6

      UniProtKB/TrEMBL
      A0A8I6ACS8
      Conserved Domains (2) summary
      sd00017
      Location:360 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:45 → 229
      DUF4195; Domain of unknown function (DUF4195)

    6. XM_008766289.3 → XP_008764511.1  zinc finger protein 280D isoform X4

      UniProtKB/TrEMBL
      A0A8I6ACS8
      Related
      ENSRNOP00000089893.1, ENSRNOT00000095837.2
      Conserved Domains (2) summary
      sd00017
      Location:360 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:45 → 229
      DUF4195; Domain of unknown function (DUF4195)

    7. XM_063265546.1 → XP_063121616.1  zinc finger protein 280D isoform X10

    8. XM_039081513.2 → XP_038937441.1  zinc finger protein 280D isoform X2

      UniProtKB/TrEMBL
      F1M0V0
      Related
      ENSRNOP00000108307.1, ENSRNOT00000133119.1
      Conserved Domains (3) summary
      sd00017
      Location:347 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:310 → 344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:32 → 215
      DUF4195; Domain of unknown function (DUF4195)

    9. XM_006243357.5 → XP_006243419.1  zinc finger protein 280D isoform X2

      See identical proteins and their annotated locations for XP_006243419.1

      UniProtKB/TrEMBL
      F1M0V0
      Conserved Domains (3) summary
      sd00017
      Location:347 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:310 → 344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:32 → 215
      DUF4195; Domain of unknown function (DUF4195)

    10. XM_063265542.1 → XP_063121612.1  zinc finger protein 280D isoform X5

      UniProtKB/TrEMBL
      A0A8I6ACS8

    11. XM_017595665.3 → XP_017451154.1  zinc finger protein 280D isoform X2

      UniProtKB/TrEMBL
      F1M0V0
      Related
      ENSRNOP00000068646.3, ENSRNOT00000089335.3
      Conserved Domains (3) summary
      sd00017
      Location:347 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:310 → 344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:32 → 215
      DUF4195; Domain of unknown function (DUF4195)

    12. XM_017595666.3 → XP_017451155.1  zinc finger protein 280D isoform X2

      UniProtKB/TrEMBL
      F1M0V0
      Conserved Domains (3) summary
      sd00017
      Location:347 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:310 → 344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:32 → 215
      DUF4195; Domain of unknown function (DUF4195)

    13. XM_039081512.2 → XP_038937440.1  zinc finger protein 280D isoform X2

      UniProtKB/TrEMBL
      F1M0V0
      Conserved Domains (3) summary
      sd00017
      Location:347 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:310 → 344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13836
      Location:32 → 215
      DUF4195; Domain of unknown function (DUF4195)

    14. XM_063265543.1 → XP_063121613.1  zinc finger protein 280D isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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