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    Ascl1 achaete-scute family bHLH transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64186, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ascl1provided by RGD
    Official Full Name
    achaete-scute family bHLH transcription factor 1provided by RGD
    Primary source
    RGD:71010
    See related
    EnsemblRapid:ENSRNOG00000085519 AllianceGenome:RGD:71010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mash1
    Summary
    Enables double-stranded DNA binding activity and identical protein binding activity. Involved in several processes, including cellular response to magnetism; regulation of neuron differentiation; and response to retinoic acid. Predicted to be located in neuronal cell body and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Biomarker of status epilepticus. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 78.3), Brain (RPKM 16.7) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ascl1 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (23790642..23793509, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (21903136..21906003, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (28038662..28040504, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093792 Neighboring gene uncharacterized LOC134479793 Neighboring gene phenylalanine hydroxylase Neighboring gene mesoderm posterior bHLH transcription factor 2, pseudogene 1 Neighboring gene uncharacterized LOC120093845

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within GABAergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adrenal chromaffin cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within carotid body glomus cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to magnetism IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex GABAergic interneuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in forebrain neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within generation of neurons ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within lung neuroendocrine cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within motor neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within musculoskeletal movement, spinal reflex action ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuroblast fate determination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuroendocrine cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neuron fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron fate specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in noradrenergic neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in noradrenergic neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in noradrenergic neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within olfactory pit development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oligodendrocyte cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pattern specification process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peripheral nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of timing of subpallium neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to epidermal growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to folic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within spinal cord association neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spinal cord oligodendrocyte cell fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within stomach neuroendocrine cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within subpallium neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sympathetic ganglion development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sympathetic ganglion development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ventral spinal cord interneuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventral spinal cord interneuron fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within vestibular nucleus development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    achaete-scute homolog 1
    Names
    achaete-scute complex homolog 1
    achaete-scute complex homolog-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022384.2NP_071779.1  achaete-scute homolog 1

      See identical proteins and their annotated locations for NP_071779.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P19359
      UniProtKB/TrEMBL
      A6IFL1
      Related
      ENSRNOP00000107713.1, ENSRNOT00000162977.1
      Conserved Domains (1) summary
      smart00353
      Location:131173
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      23790642..23793509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)