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    Defb14 defensin beta 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 641627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Defb14provided by RGD
    Official Full Name
    defensin beta 14provided by RGD
    Primary source
    RGD:1561378
    See related
    EnsemblRapid:ENSRNOG00000032304 AllianceGenome:RGD:1561378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis and defense response to other organism. Predicted to act upstream of or within positive chemotaxis and signal transduction. Predicted to be active in extracellular space. Orthologous to several human genes including DEFB103A (defensin beta 103A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 32.9) See more
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    Genomic context

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    See Defb14 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77365892..77369668, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70663443..70668473, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75647523..75650913, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene defensin beta 5 Neighboring gene defensin beta 4 Neighboring gene uncharacterized LOC134482415 Neighboring gene sperm associated antigen 11A Neighboring gene sperm associated antigen 11b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. Maisetta G, et al. Antimicrob Agents Chemother, 2006 Feb. PMID 16436752, Free PMC Article
    2. Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3. Röhrl J, et al. J Biol Chem, 2008 Feb 29. PMID 18167348
    3. Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. Harder J, et al. J Biol Chem, 2001 Feb 23. PMID 11085990
    4. Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. Schulz A, et al. Biopolymers, 2005. PMID 15625724
    5. Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal. Augustin DK, et al. Infect Immun, 2011 Feb. PMID 21115716, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CCR6 chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in killing by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-defensin 14
    Names
    BD-14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037504.2 → NP_001032593.1  beta-defensin 14 precursor

      See identical proteins and their annotated locations for NP_001032593.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q32ZH7
      UniProtKB/TrEMBL
      A6IWA4
      Related
      ENSRNOP00000048330.1, ENSRNOT00000048414.3
      Conserved Domains (1) summary
      pfam00711
      Location:30 → 64
      Defensin_beta; Beta defensin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      77365892..77369668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253372.4 → XP_006253434.1  beta-defensin 14 isoform X1

      See identical proteins and their annotated locations for XP_006253434.1

      UniProtKB/Swiss-Prot
      Q32ZH7
      UniProtKB/TrEMBL
      A6IWA4
      Conserved Domains (1) summary
      pfam00711
      Location:30 → 64
      Defensin_beta; Beta defensin

    2. XM_017600241.3 → XP_017455730.1  beta-defensin 14 isoform X1

      UniProtKB/Swiss-Prot
      Q32ZH7
      UniProtKB/TrEMBL
      A6IWA4
      Conserved Domains (1) summary
      pfam00711
      Location:30 → 64
      Defensin_beta; Beta defensin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32ZH7.1 GenPept UniProtKB/Swiss-Prot:Q32ZH7

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