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    Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171352, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyp3a9provided by RGD
    Official Full Name
    cytochrome P450, family 3, subfamily a, polypeptide 9provided by RGD
    Primary source
    RGD:708392
    See related
    EnsemblRapid:ENSRNOG00000046643 AllianceGenome:RGD:708392
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp3a13; P450olf3
    Summary
    Predicted to enable estrogen 16-alpha-hydroxylase activity; retinoic acid 4-hydroxylase activity; and testosterone 6-beta-hydroxylase activity. Involved in several processes, including response to dexamethasone; response to estradiol; and response to estrogen. Predicted to be located in endoplasmic reticulum membrane. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough) and CYP3A7 (cytochrome P450 family 3 subfamily A member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 464.2) See more
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    Genomic context

    See Cyp3a9 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (21919955..21960160, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (16806222..16846428, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19074288..19114491, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481269 Neighboring gene tubulin, beta 4B class IVb, pseudogene 2 Neighboring gene sprouty RTK signaling antagonist 3 Neighboring gene vesicle-associated membrane protein 7 Neighboring gene olfactory receptor pseudogene 1574-like Neighboring gene ribosomal protein L31 like 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93139

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in alkaloid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in lipid hydroxylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oxidative demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oxidative demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to dexamethasone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in retinoic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 3A9
    Names
    3AH15
    CYPIIIA9
    P450-OLF3
    cytochrome P450 olfactive 3
    cytochrome P450, family 3, subfamily a, polypeptide 13
    cytochrome P450-OLF3
    olfactive
    olfactory cytochrome P450olf3
    NP_671739.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_147206.2NP_671739.2  cytochrome P450 3A9

      See identical proteins and their annotated locations for NP_671739.2

      Status: PROVISIONAL

      Source sequence(s)
      BC086985
      UniProtKB/Swiss-Prot
      P51538, Q64557, Q64631
      UniProtKB/TrEMBL
      A0A9K3Y7I1, M0RDI0, Q5PQX2
      Related
      ENSRNOP00000067681.3, ENSRNOT00000073099.4
      Conserved Domains (1) summary
      pfam00067
      Location:39493
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      21919955..21960160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)