Tbx20 T-box transcription factor 20 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tbx20provided by RGD
Official Full Name: T-box transcription factor 20provided by RGD
Primary source: RGD:1309396
See related: EnsemblRapid:ENSRNOG00000016181 AllianceGenome:RGD:1309396
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of apoptotic process and positive regulation of cell cycle process. Predicted to be located in chromatin and cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in atrial heart septal defect; atrial heart septal defect 4; congenital heart disease; tetralogy of Fallot; and ventricular septal defect. Orthologous to human TBX20 (T-box transcription factor 20). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 497.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (31475963..31534051, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (23200104..23258218, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (25849394..25904570, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of TBX20 in rat myocardial and human embryonic kidney cells significantly inhibited cell proliferation, induced cell apoptosis and led to G2/M cell cycle arrest.
Title: Silencing of TBX20 gene expression in rat myocardial and human embryonic kidney cells leads to cell cycle arrest in G2 phase.
Cardiac TBX20 expression showed a negative correlation with LVEF and a positive correlation with left ventricular end-systolic volume. No significant difference in TBX20 CNVs and promoter methylation was observed between IDCM patients and control group
Title: Role of cardiac TBX20 in dilated cardiomyopathy.

Submit: New GeneRIF Correction

General gene information

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Markers

D8Got28 (e-PCR)
- UniSTS:114002

TBX20 (e-PCR)
- UniSTS:503640

Tbx20 (e-PCR), detects polymorphism
- UniSTS:474761

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aortic valve development	ISO Inferred from Sequence Orthology more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrial septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular canal development	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular valve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac chamber formation	ISO Inferred from Sequence Orthology more info
involved_in cardiac chamber formation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac right ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac septum development	ISO Inferred from Sequence Orthology more info
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	ISO Inferred from Sequence Orthology more info
involved_in embryonic heart tube elongation	ISO Inferred from Sequence Orthology more info
involved_in embryonic heart tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in foramen ovale closure	ISO Inferred from Sequence Orthology more info
involved_in heart looping	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart looping	ISO Inferred from Sequence Orthology more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motor neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in pericardium morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve formation	ISO Inferred from Sequence Orthology more info
involved_in pulmonary vein morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricuspid valve development	ISO Inferred from Sequence Orthology more info
involved_in visceral motor neuron differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-box transcription factor TBX20

Names: T-box 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108132.2 → NP_001101602.1 T-box transcription factor TBX20 isoform 2

See identical proteins and their annotated locations for NP_001101602.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6JYB1, A6JYB2, D3ZUF4

Related

ENSRNOP00000063295.2, ENSRNOT00000064783.4

Conserved Domains (1) summary

cd00182
Location:99 → 291

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
NM_001401090.1 → NP_001388019.1 T-box transcription factor TBX20 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2KAH3, A6JYB0

Related

ENSRNOP00000075397.1, ENSRNOT00000082744.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

31475963..31534051 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081364.2 → XP_038937292.1 T-box transcription factor TBX20 isoform X1

Conserved Domains (2) summary

pfam05872
Location:280 → 368

DUF853; Bacterial protein of unknown function (DUF853)

cd20193
Location:60 → 249

T-box_TBX20-like; DNA-binding domain of T-box transcription factor 20 and related T-box proteins
XM_063265373.1 → XP_063121443.1 T-box transcription factor TBX20 isoform X2