Satb2 SATB homeobox 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Satb2provided by RGD
Official Full Name: SATB homeobox 2provided by RGD
Primary source: RGD:1562369
See related: EnsemblRapid:ENSRNOG00000010188 AllianceGenome:RGD:1562369
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562369
Summary: Enables histone deacetylase binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including osteoblast development; regulation of transcription by RNA polymerase II; and skeletal system development. Predicted to be located in nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB2 (SATB homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 37.1), Brain (RPKM 36.2) and 2 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9q31

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (65842351..66028569, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (58348027..58534256, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (63456877..63642193, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-1301 promotes adipogenic and osteogenic differentiation of BMSCs by targeting Satb2.
Title: MiR-1301 promotes adipogenic and osteogenic differentiation of BMSCs by targeting Satb2.
Maternal regulation of SATB2 in osteo-progeniters impairs skeletal development in offspring.
Title: Maternal regulation of SATB2 in osteo-progeniters impairs skeletal development in offspring.
MicroRNA-449b-5p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of BMSCs via targeting Satb2.
Title: MicroRNA-449b-5p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of BMSCs via targeting Satb2.
bone marrow stromal cells from the OVX rats displayed increased senescence and weaker SATB2 expression, stemness, and osteogenic differentiation, while estrogen could rescue these phenotypes. Inhibition of ERb or ERa confirmed that SATB2 was associated with ERb in estrogen-mediated pluripotency and senescence of BMSCs.
Title: Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ERβ-SATB2 pathway.
miR-34b/c participates in aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway.
Title: MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway.
Satb2 may also be related to the establishment of species-specific neuropeptide co-phenotypes during postnatal development.
Title: Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents.
miR-31 diminishes the levels of the Satb2 protein without significantly affecting Satb2 mRNA levels, and Runx2 directly represses miR-31 expression, a mechanism that may play an important role in inducing osteogenic differentiation.
Title: Effects of a miR-31, Runx2, and Satb2 regulatory loop on the osteogenic differentiation of bone mesenchymal stem cells.
Matrix attachment region protein Satb2 demonstrates a function in growth factor-dependent neurotransmitter plasticity in postmitotic neurons.
Title: The sympathetic neurotransmitter switch depends on the nuclear matrix protein Satb2.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH140688 (e-PCR)
- UniSTS:222756

RH80503 (e-PCR)
- UniSTS:87202

RH143932 (e-PCR)
- UniSTS:233178

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: DNA-binding protein SATB2

Names: special AT-rich sequence binding protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109306.1 → NP_001102776.1 DNA-binding protein SATB2

See identical proteins and their annotated locations for NP_001102776.1

Status: PROVISIONAL

Source sequence(s)

CH473965

UniProtKB/TrEMBL

A6IP31, D3ZJ19

Related

ENSRNOP00000087808.2, ENSRNOT00000107325.2

Conserved Domains (4) summary

smart00389
Location:614 → 671

HOX; Homeodomain

cd11585
Location:60 → 155

SATB1_N; N-terminal domain of SATB1 and similar proteins

pfam02376
Location:477 → 556

CUT; CUT domain

pfam16557
Location:162 → 232

CUTL; CUT1-like DNA-binding domain of SATB

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

65842351..66028569 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596603.3 → XP_017452092.1 DNA-binding protein SATB2 isoform X1

UniProtKB/TrEMBL

A0A8I6AHD9, D3ZJ19

Conserved Domains (4) summary

smart00389
Location:621 → 678

HOX; Homeodomain

cd11585
Location:67 → 162

SATB1_N; N-terminal domain of SATB1 and similar proteins

pfam02376
Location:484 → 563

CUT; CUT domain

pfam16557
Location:169 → 239

CUTL; CUT1-like DNA-binding domain of SATB
XM_008767129.4 → XP_008765351.1 DNA-binding protein SATB2 isoform X1

UniProtKB/TrEMBL

A0A8I6AHD9, D3ZJ19

Conserved Domains (4) summary

smart00389
Location:621 → 678

HOX; Homeodomain

cd11585
Location:67 → 162

SATB1_N; N-terminal domain of SATB1 and similar proteins

pfam02376
Location:484 → 563

CUT; CUT domain

pfam16557
Location:169 → 239

CUTL; CUT1-like DNA-binding domain of SATB
XM_063267604.1 → XP_063123674.1 DNA-binding protein SATB2 isoform X2

UniProtKB/TrEMBL

A0A0G2JZH5, D3ZJ19

Related

ENSRNOP00000071049.2, ENSRNOT00000087684.3