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    Kcnmb2 potassium calcium-activated channel subfamily M regulatory beta subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294961, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnmb2provided by RGD
    Official Full Name
    potassium calcium-activated channel subfamily M regulatory beta subunit 2provided by RGD
    Primary source
    RGD:631398
    See related
    EnsemblRapid:ENSRNOG00000010094 AllianceGenome:RGD:631398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kcmb2
    Summary
    Enables potassium channel activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human KCNMB2 (potassium calcium-activated channel subfamily M regulatory beta subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 31.5), Lung (RPKM 29.5) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnmb2 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (116598511..116903886)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (114670027..114975374)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (118276298..118585321)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene EGF-like and EMI domain containing 1 Neighboring gene microRNA 551b Neighboring gene uncharacterized LOC134485730 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene zinc finger, matrin type 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons. Li W, et al. J Cell Physiol, 2007 Aug. PMID 17523149
    2. Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent. Bukiya AN, et al. Mol Pharmacol, 2013 May. PMID 23455312, Free PMC Article
    3. Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea. Langer P, et al. J Comp Neurol, 2003 Jan 6. PMID 12454985
    4. Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells. Xia XM, et al. J Neurosci, 1999 Jul 1. PMID 10377337, Free PMC Article
    5. Voltage-sensitive oxonol dyes are novel large-conductance Ca2+-activated K+ channel activators selective for beta1 and beta4 but not for beta2 subunits. Morimoto T, et al. Mol Pharmacol, 2007 Apr. PMID 17209121

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kcnmb2 is responsible for inactivating large-conductance calcium-dependent potassium currents in small sensory dorsal root ganglion neurons.
      Title: Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons.
    2. DiBAC(4)(3) activated whole-cell BKalphabeta1 and BKalphabeta4 currents in the same concentration range but partially blocked BKalphabeta2 currents. Structure activity relationships are discussed.
      Title: Voltage-sensitive oxonol dyes are novel large-conductance Ca2+-activated K+ channel activators selective for beta1 and beta4 but not for beta2 subunits.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-activated potassium channel subunit beta-2
    Names
    BK channel subunit beta-2
    BKbeta2
    calcium-activated potassium channel beta 2
    calcium-activated potassium channel, subfamily M subunit beta-2
    charybdotoxin receptor subunit beta-2
    k(VCA)beta-2
    maxi K channel subunit beta-2
    potassium channel subfamily M regulatory beta subunit 2
    potassium large conductance calcium-activated channel, subfamily M, beta member 2
    rbeta3
    slo-beta-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176861.2 → NP_789831.2  calcium-activated potassium channel subunit beta-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q811Q0, Q8CF83
      UniProtKB/TrEMBL
      A0A0G2K0A6, A6IHN2
      Related
      ENSRNOP00000104648.1, ENSRNOT00000139108.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      116598511..116903886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590737.3 → XP_017446226.1  calcium-activated potassium channel subunit beta-2 isoform X2

      UniProtKB/Swiss-Prot
      Q811Q0, Q8CF83
      UniProtKB/TrEMBL
      A0A0G2K0A6, A6IHN2
      Conserved Domains (2) summary
      pfam03185
      Location:38 → 229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:2 → 32
      KcnmB2_inactiv; KCNMB2, ball and chain domain

    2. XM_063281561.1 → XP_063137631.1  calcium-activated potassium channel subunit beta-2 isoform X2

      UniProtKB/Swiss-Prot
      Q811Q0, Q8CF83
      UniProtKB/TrEMBL
      A0A0G2K0A6, A6IHN2

    3. XM_063281560.1 → XP_063137630.1  calcium-activated potassium channel subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A6IHN1
      Related
      ENSRNOP00000071367.2, ENSRNOT00000079254.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q811Q0.1 GenPept UniProtKB/Swiss-Prot:Q811Q0

    Gene LinkOut

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