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    Dctn4 dynactin subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dctn4provided by RGD
    Official Full Name
    dynactin subunit 4provided by RGD
    Primary source
    RGD:71023
    See related
    EnsemblRapid:ENSRNOG00000019298 AllianceGenome:RGD:71023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Located in cytoskeleton; focal adhesion; and kinetochore. Part of cytoplasmic dynein complex. Orthologous to human DCTN4 (dynactin subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 156.9), Brain (RPKM 140.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dctn4 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (56251187..56279844)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (53982355..54009409)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (55797188..55824195)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene interferon-gamma-inducible GTPase 2 like 2 Neighboring gene interferon-gamma-inducible GTPase 2 like, pseudogene 1 Neighboring gene small integral membrane protein 3 Neighboring gene RNA binding motif protein 22 Neighboring gene myozenin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction of the p62 subunit of dynactin with Arp1 and the cortical actin cytoskeleton. Garces JA, et al. Curr Biol, 1999 Dec 16-30. PMID 10607597
    2. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. Lim CM, et al. J Biol Chem, 2006 May 19. PMID 16554302
    3. Dynactin. Schroer TA. Annu Rev Cell Dev Biol, 2004. PMID 15473859
    4. Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end. Eckley DM, et al. J Cell Biol, 1999 Oct 18. PMID 10525537, Free PMC Article
    5. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC114292

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic dynein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynactin subunit 4
    Names
    dynactin 4 (p62)
    dynactin subunit p62

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433422.1 → NP_001420351.1  dynactin subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6A638, Q498N3

    2. NM_053404.3 → NP_445856.1  dynactin subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_445856.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q9QUR2, Q9QXP8
      UniProtKB/TrEMBL
      A0A8I6A638, A6IXB2
      Related
      ENSRNOP00000026394.3, ENSRNOT00000026394.8
      Conserved Domains (1) summary
      pfam05502
      Location:23 → 348
      Dynactin_p62; Dynactin p62 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      56251187..56279844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254783.5 → XP_006254845.1  dynactin subunit 4 isoform X1

      Related
      ENSRNOP00000086389.2, ENSRNOT00000097384.2
      Conserved Domains (1) summary
      pfam05502
      Location:23 → 341
      Dynactin_p62; Dynactin p62 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUR2.1 GenPept UniProtKB/Swiss-Prot:Q9QUR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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