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    Slc2a10 solute carrier family 2 member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366251, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc2a10provided by RGD
    Official Full Name
    solute carrier family 2 member 10provided by RGD
    Primary source
    RGD:1306552
    See related
    EnsemblRapid:ENSRNOG00000025384 AllianceGenome:RGD:1306552
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and symporter activity. Predicted to be involved in D-glucose import across plasma membrane; circulatory system development; and dehydroascorbic acid transport. Predicted to act upstream of or within several processes, including cell redox homeostasis; regulation of macromolecule biosynthetic process; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in arterial tortuosity syndrome. Orthologous to human SLC2A10 (solute carrier family 2 member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 33.4), Uterus (RPKM 14.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Slc2a10 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (174659683..174671978)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (154240395..154252690)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (162182156..162194610)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 2 Neighboring gene solute carrier family 13 member 3 Neighboring gene uncharacterized LOC134486203 Neighboring gene Tp53 tumor protein p53 regulating kinase A Neighboring gene uncharacterized LOC120101927 Neighboring gene EYA transcriptional coactivator and phosphatase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dehydroascorbic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in D-glucose import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in D-glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within artery development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circulatory system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dehydroascorbic acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic skeletal joint development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of connective tissue growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skin development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 10
    Names
    solute carrier family 2 (facilitated glucose transporter), member 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108963.1NP_001102433.1  solute carrier family 2, facilitated glucose transporter member 10

      See identical proteins and their annotated locations for NP_001102433.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474005
      UniProtKB/TrEMBL
      A0A8I6ADR5, A6JXF7
      Related
      ENSRNOP00000090543.1, ENSRNOT00000109062.2
      Conserved Domains (2) summary
      cd06174
      Location:14330
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:11508
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      174659683..174671978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)