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    Hectd2 HECT domain E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hectd2provided by RGD
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 2provided by RGD
    Primary source
    RGD:1305536
    See related
    EnsemblRapid:ENSRNOG00000056753 AllianceGenome:RGD:1305536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Orthologous to human HECTD2 (HECT domain E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 90.1), Heart (RPKM 83.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hectd2 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (243687248..243756069)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (234274967..234345598)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (255186729..255254307)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 5 Neighboring gene uncharacterized LOC103691349 Neighboring gene uncharacterized LOC134485231 Neighboring gene uncharacterized LOC120100025 Neighboring gene protein phosphatase 1, regulatory subunit 3C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HECTD2
    Names
    HECT domain containing 2
    HECT domain containing E3 ubiquitin protein ligase 2
    NP_001101078.3
    XP_038936564.1
    XP_038936565.1
    XP_038936567.1
    XP_063121284.1
    XP_063121294.1
    XP_063121298.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107608.3 → NP_001101078.3  probable E3 ubiquitin-protein ligase HECTD2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I154
      Related
      ENSRNOP00000070631.3, ENSRNOT00000086991.3
      Conserved Domains (1) summary
      cd00078
      Location:415 → 772
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      243687248..243756069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080637.2 → XP_038936565.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

      UniProtKB/TrEMBL
      A6I154
      Conserved Domains (1) summary
      cd00078
      Location:454 → 811
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. XM_063265214.1 → XP_063121284.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

      UniProtKB/TrEMBL
      A6I154

    3. XM_063265228.1 → XP_063121298.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X6

    4. XM_039080639.2 → XP_038936567.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X4

      Conserved Domains (1) summary
      cl27008
      Location:416 → 506
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    5. XM_039080636.2 → XP_038936564.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYF3, A6I154
      Conserved Domains (1) summary
      cd00078
      Location:416 → 773
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    6. XM_063265224.1 → XP_063121294.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X5

    RNA

    1. XR_010053954.1 RNA Sequence

    2. XR_010053955.1 RNA Sequence

    3. XR_005487723.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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