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    Gramd1c GRAM domain containing 1C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360717, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gramd1cprovided by RGD
    Official Full Name
    GRAM domain containing 1Cprovided by RGD
    Primary source
    RGD:1305433
    See related
    EnsemblRapid:ENSRNOG00000053406 AllianceGenome:RGD:1305433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305433
    Summary
    Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol. Predicted to be located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Orthologous to human GRAMD1C (GRAM domain containing 1C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 171.1), Testes (RPKM 124.0) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gramd1c in Genome Data Viewer
    Location:
    11q21
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (70139076..70224478)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56633229..56718570)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61609370..61659355) , (62580983..62634961)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095658 Neighboring gene N(alpha)-acetyltransferase 50, NatE catalytic subunit Neighboring gene ATPase H+ transporting V1 subunit A Neighboring gene uncharacterized LOC134481070 Neighboring gene zinc finger DHHC-type palmitoyltransferase 23 Neighboring gene coiled-coil domain containing 191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Sandhu J, et al. Cell, 2018 Oct 4. PMID 30220461, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cholesterol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum-plasma membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Aster-C
    Names
    GRAM domain-containing protein 1C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191826.2 → NP_001178755.1  protein Aster-C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6AME7, A6IR16
      Related
      ENSRNOP00000090140.1, ENSRNOT00000093588.3
      Conserved Domains (2) summary
      cd13220
      Location:80 → 173
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:330 → 477
      DUF4782; Domain of unknown function (DUF4782)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      70139076..70224478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088482.2 → XP_038944410.1  protein Aster-C isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q6J4
      Related
      ENSRNOP00000069253.3, ENSRNOT00000088880.3
      Conserved Domains (2) summary
      cd13220
      Location:101 → 194
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:351 → 498
      DUF4782; Domain of unknown function (DUF4782)

    2. XM_039088485.2 → XP_038944413.1  protein Aster-C isoform X4

      Conserved Domains (2) summary
      cd13220
      Location:101 → 194
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:338 → 452
      DUF4782; Domain of unknown function (DUF4782)

    3. XM_039088484.1 → XP_038944412.1  protein Aster-C isoform X3

      UniProtKB/TrEMBL
      A0A1W2Q652
      Conserved Domains (2) summary
      pfam16016
      Location:319 → 466
      DUF4782; Domain of unknown function (DUF4782)
      cl17171
      Location:101 → 162
      PH-like; Pleckstrin homology-like domain

    4. XM_039088483.2 → XP_038944411.1  protein Aster-C isoform X2

      UniProtKB/TrEMBL
      A6IR16
      Related
      ENSRNOP00000076277.3, ENSRNOT00000093242.3
      Conserved Domains (2) summary
      cd13220
      Location:78 → 171
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:328 → 475
      DUF4782; Domain of unknown function (DUF4782)

    5. XM_063270638.1 → XP_063126708.1  protein Aster-C isoform X5

      UniProtKB/TrEMBL
      A6IR16
    Nucleotide Protein Strain
    Heading Accession and Version

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