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    Lcorl ligand dependent nuclear receptor corepressor-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498385, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lcorlprovided by RGD
    Official Full Name
    ligand dependent nuclear receptor corepressor-likeprovided by RGD
    Primary source
    RGD:1561241
    See related
    EnsemblRapid:ENSRNOG00000003787 AllianceGenome:RGD:1561241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561241
    Summary
    Predicted to enable histone methyltransferase binding activity. Predicted to act upstream of or within regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 64.9), Kidney (RPKM 63.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lcorl in Genome Data Viewer
    Location:
    14q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (69482919..69620269)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (65271339..65407732)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (69765356..69898749)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC134481688 Neighboring gene RNA polymerase III subunit F, pseudogene 2 Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 5 Neighboring gene non-SMC condensin I complex, subunit G Neighboring gene DDB1 and CUL4 associated factor 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ligand-dependent nuclear receptor corepressor-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432820.1 → NP_001419749.1  ligand-dependent nuclear receptor corepressor-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    2. NM_001432821.1 → NP_001419750.1  ligand-dependent nuclear receptor corepressor-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6G435, A0A8I6GLM1

    3. NM_001432822.1 → NP_001419751.1  ligand-dependent nuclear receptor corepressor-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      69482919..69620269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599472.3 → XP_017454961.2  ligand-dependent nuclear receptor corepressor-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1424 → 1874
      DUF4553; Domain of unknown function (DUF4553)

    2. XM_039092775.2 → XP_038948703.1  ligand-dependent nuclear receptor corepressor-like protein isoform X13

    3. XM_017599474.3 → XP_017454963.2  ligand-dependent nuclear receptor corepressor-like protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1398 → 1848
      DUF4553; Domain of unknown function (DUF4553)

    4. XM_039092776.2 → XP_038948704.1  ligand-dependent nuclear receptor corepressor-like protein isoform X14

    5. XM_063273773.1 → XP_063129843.1  ligand-dependent nuclear receptor corepressor-like protein isoform X15

    6. XM_017599475.3 → XP_017454964.2  ligand-dependent nuclear receptor corepressor-like protein isoform X7

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1328 → 1778
      DUF4553; Domain of unknown function (DUF4553)

    7. XM_017599473.3 → XP_017454962.2  ligand-dependent nuclear receptor corepressor-like protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1424 → 1874
      DUF4553; Domain of unknown function (DUF4553)

    8. XM_008770224.4 → XP_008768446.3  ligand-dependent nuclear receptor corepressor-like protein isoform X11

      UniProtKB/TrEMBL
      A0A8I6G435
      Related
      ENSRNOP00000095424.2, ENSRNOT00000101649.2
      Conserved Domains (1) summary
      pfam05225
      Location:551 → 596
      HTH_psq; helix-turn-helix, Psq domain

    9. XM_039092774.2 → XP_038948702.1  ligand-dependent nuclear receptor corepressor-like protein isoform X12

      Related
      ENSRNOP00000091243.1, ENSRNOT00000100583.2
      Conserved Domains (1) summary
      pfam05225
      Location:525 → 570
      HTH_psq; helix-turn-helix, Psq domain

    10. XM_039092778.2 → XP_038948706.1  ligand-dependent nuclear receptor corepressor-like protein isoform X17

    11. XM_039092777.2 → XP_038948705.1  ligand-dependent nuclear receptor corepressor-like protein isoform X16

    12. XM_039092771.2 → XP_038948699.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1312 → 1762
      DUF4553; Domain of unknown function (DUF4553)

    13. XM_017599481.3 → XP_017454970.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1312 → 1762
      DUF4553; Domain of unknown function (DUF4553)

    14. XM_063273771.1 → XP_063129841.1  ligand-dependent nuclear receptor corepressor-like protein isoform X10

      UniProtKB/TrEMBL
      A0A8I6A139

    15. XM_039092768.2 → XP_038948696.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1315 → 1765
      DUF4553; Domain of unknown function (DUF4553)

    16. XM_017599482.3 → XP_017454971.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1312 → 1762
      DUF4553; Domain of unknown function (DUF4553)

    17. XM_039092761.2 → XP_038948689.1  ligand-dependent nuclear receptor corepressor-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1390 → 1840
      DUF4553; Domain of unknown function (DUF4553)

    18. XM_039092767.2 → XP_038948695.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1315 → 1765
      DUF4553; Domain of unknown function (DUF4553)

    19. XM_063273770.1 → XP_063129840.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

      UniProtKB/TrEMBL
      A0A8I6A139

    20. XM_039092772.2 → XP_038948700.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1312 → 1762
      DUF4553; Domain of unknown function (DUF4553)

    21. XM_039092760.2 → XP_038948688.1  ligand-dependent nuclear receptor corepressor-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1390 → 1840
      DUF4553; Domain of unknown function (DUF4553)

    22. XM_039092762.2 → XP_038948690.1  ligand-dependent nuclear receptor corepressor-like protein isoform X5

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1364 → 1814
      DUF4553; Domain of unknown function (DUF4553)

    23. XM_063273763.1 → XP_063129833.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6A139

    24. XM_063273765.1 → XP_063129835.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6A139

    25. XM_063273766.1 → XP_063129836.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6A139

    26. XM_063273764.1 → XP_063129834.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6A139

    27. XM_063273769.1 → XP_063129839.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6A139

    28. XM_063273762.1 → XP_063129832.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6A139

    29. XM_039092769.2 → XP_038948697.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1315 → 1765
      DUF4553; Domain of unknown function (DUF4553)

    30. XM_063273768.1 → XP_063129838.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6A139

    31. XM_063273767.1 → XP_063129837.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6A139

    32. XM_017599479.3 → XP_017454968.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1315 → 1765
      DUF4553; Domain of unknown function (DUF4553)

    33. XM_063273772.1 → XP_063129842.1  ligand-dependent nuclear receptor corepressor-like protein isoform X10

      UniProtKB/TrEMBL
      A0A8I6A139

    34. XM_039092773.2 → XP_038948701.1  ligand-dependent nuclear receptor corepressor-like protein isoform X10

      UniProtKB/TrEMBL
      A0A8I6A139
      Conserved Domains (1) summary
      pfam15090
      Location:1239 → 1689
      DUF4553; Domain of unknown function (DUF4553)
    Nucleotide Protein Strain
    Heading Accession and Version

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